[HTML][HTML] Variants in the vitamin D pathway, serum levels of vitamin D, and estrogen receptor negative breast cancer among African-American women: a case-control …
Abstract Introduction American women of African ancestry (AA) are more likely than
European Americans (EA) to have estrogen receptor (ER)-negative breast cancer. 25 …
European Americans (EA) to have estrogen receptor (ER)-negative breast cancer. 25 …
Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes
A Murphy, JH Chu, M Xu, VJ Carey… - Human molecular …, 2010 - academic.oup.com
Genome-wide association studies of human gene expression promise to identify functional
regulatory genetic variation that contributes to phenotypic diversity. However, it is unclear …
regulatory genetic variation that contributes to phenotypic diversity. However, it is unclear …
Consistency of genome-wide associations across major ancestral groups
EE Ntzani, G Liberopoulos, TA Manolio, JPA Ioannidis - Human genetics, 2012 - Springer
It is not well known whether genetic markers identified through genome-wide association
studies (GWAS) confer similar or different risks across people of different ancestry. We …
studies (GWAS) confer similar or different risks across people of different ancestry. We …
Integrating microRNAs into a system biology approach to acute lung injury
Acute lung injury (ALI), including the ventilator-induced lung injury (VILI) and the more
severe acute respiratory distress syndrome (ARDS), are common and complex inflammatory …
severe acute respiratory distress syndrome (ARDS), are common and complex inflammatory …
[HTML][HTML] Effects of cis and trans Genetic Ancestry on Gene Expression in African Americans
Variation in gene expression is a fundamental aspect of human phenotypic variation.
Several recent studies have analyzed gene expression levels in populations of different …
Several recent studies have analyzed gene expression levels in populations of different …
[HTML][HTML] A genome-wide survey for SNPs altering microRNA seed sites identifies functional candidates in GWAS
K Richardson, CQ Lai, LD Parnell, YC Lee, JM Ordovas - BMC genomics, 2011 - Springer
Background Gene variants within regulatory regions are thought to be major contributors of
the variation of complex traits/diseases. Genome wide association studies (GWAS), have …
the variation of complex traits/diseases. Genome wide association studies (GWAS), have …
Worldwide patterns of human epigenetic variation
DNA methylation is an epigenetic modification, influenced by both genetic and
environmental variation, that plays a key role in transcriptional regulation and many …
environmental variation, that plays a key role in transcriptional regulation and many …
Extensive relationship between antisense transcription and alternative splicing in the human genome
To analyze the relationship between antisense transcription and alternative splicing, we
developed a computational approach for the detection of antisense-correlated exon splicing …
developed a computational approach for the detection of antisense-correlated exon splicing …
Regulatory polymorphisms in β-tubulin IIa are associated with paclitaxel-induced peripheral neuropathy
LJ Leandro-García, S Leskelä, C Jara, H Gréen… - Clinical Cancer …, 2012 - AACR
Purpose: Peripheral neuropathy is the dose-limiting toxicity of paclitaxel, a
chemotherapeutic drug widely used to treat several solid tumors such as breast, lung, and …
chemotherapeutic drug widely used to treat several solid tumors such as breast, lung, and …
The impact of microRNA expression on cellular proliferation
As an important class of non-coding regulatory RNAs, microRNAs (miRNAs) play a key role
in a range of biological processes. These molecules serve as post-transcriptional regulators …
in a range of biological processes. These molecules serve as post-transcriptional regulators …