Targeting SARS-CoV-2 nonstructural protein 3: function, structure, inhibition, and perspective in drug discovery
As a highly contagious human pathogen, severe acute respiratory syndrome-associated
coronavirus-2 (SARS-CoV-2) has infected billions of people worldwide with more than 6 …
coronavirus-2 (SARS-CoV-2) has infected billions of people worldwide with more than 6 …
[HTML][HTML] Diagnostic and therapeutic potential of protease inhibition
N Ćwilichowska, KW Świderska, A Dobrzyń… - Molecular Aspects of …, 2022 - Elsevier
Proteases are enzymes that hydrolyze peptide bonds in proteins and peptides; thus, they
control virtually all biological processes. Our understanding of protease function has …
control virtually all biological processes. Our understanding of protease function has …
[HTML][HTML] SARS-CoV-2 proteases Mpro and PLpro: Design of inhibitors with predicted high potency and low mammalian toxicity using artificial neural networks, ligand …
RS Tumskiy, AV Tumskaia, IN Klochkova… - Computers in Biology …, 2023 - Elsevier
The main (Mpro) and papain-like (PLpro) proteases are highly conserved viral proteins
essential for replication of the COVID-19 virus, SARS-COV-2. Therefore, a logical plan for …
essential for replication of the COVID-19 virus, SARS-COV-2. Therefore, a logical plan for …
Synthesis of SARS-CoV-2 M pro inhibitors bearing a cinnamic ester warhead with in vitro activity against human coronaviruses
A Citarella, D Moi, M Pedrini, H Pérez-Peña… - Organic & …, 2023 - pubs.rsc.org
COVID-19 now ranks among the most devastating global pandemics in history. The
causative virus, SARS-CoV-2, is a new human coronavirus (hCoV) that spreads among …
causative virus, SARS-CoV-2, is a new human coronavirus (hCoV) that spreads among …
Insights into drug Repurposing, as well as specificity and compound properties of piperidine-based SARS-CoV-2 PLpro inhibitors
DJ Calleja, N Kuchel, BGC Lu, RW Birkinshaw… - Frontiers in …, 2022 - frontiersin.org
The COVID-19 pandemic continues unabated, emphasizing the need for additional antiviral
treatment options to prevent hospitalization and death of patients infected with SARS-CoV-2 …
treatment options to prevent hospitalization and death of patients infected with SARS-CoV-2 …
Large-scale virtual screening for the discovery of SARS-CoV-2 papain-like protease (PLpro) non-covalent inhibitors
The rapid global spread of the SARS-CoV-2 virus facilitated the development of novel direct-
acting antiviral agents (DAAs). The papain-like protease (PLpro) has been proposed as one …
acting antiviral agents (DAAs). The papain-like protease (PLpro) has been proposed as one …
Structure-based design of SARS-CoV-2 papain-like protease inhibitors
The COVID-19 pandemic is caused by SARS-CoV-2, an RNA virus with high transmissibility
and mutation rate. Given the paucity of orally bioavailable antiviral drugs to combat SARS …
and mutation rate. Given the paucity of orally bioavailable antiviral drugs to combat SARS …
NMR Characterization of the Papain-like Protease from SARS-CoV-2 Identifies the Conformational Heterogeneity in Its Inhibitor-Binding Site
Y Shiraishi, I Shimada - Journal of the American Chemical Society, 2023 - ACS Publications
Papain-like protease (PLpro) from severe acute respiratory syndrome Coronavirus 2 (SARS-
CoV-2) is a prime target for the development of antivirals for Coronavirus disease 2019 …
CoV-2) is a prime target for the development of antivirals for Coronavirus disease 2019 …
[HTML][HTML] Pharmacophore model-aided virtual screening combined with comparative molecular docking and molecular dynamics for identification of marine natural …
N Thangavel, M Albratty - Arabian Journal of Chemistry, 2022 - Elsevier
Abstract Targeting SARS-CoV-2 papain-like protease using inhibitors is a suitable approach
for inhibition of virus replication and dysregulation of host anti-viral immunity. Engaging all …
for inhibition of virus replication and dysregulation of host anti-viral immunity. Engaging all …
Identification, optimization, and biological evaluation of 3-O-β-chacotriosyl ursolic acid derivatives as novel SARS-CoV-2 entry inhibitors by targeting the prefusion …
H Li, C Cheng, S Shi, Y Wu, Y Gao, Z Liu, M Liu… - European Journal of …, 2022 - Elsevier
The COVID-19 pandemic generates a global threat to public health and continuously
emerging SARS-CoV-2 variants bring a great challenge to the development of both vaccines …
emerging SARS-CoV-2 variants bring a great challenge to the development of both vaccines …