Targeting papain-like protease by natural products as novel therapeutic potential SARS-CoV-2
The highly infectious respiratory illness 'COVID-19'was caused by SARS-CoV-2 and is
responsible for millions of deaths. SARS-single-stranded viral RNA genome encodes …
responsible for millions of deaths. SARS-single-stranded viral RNA genome encodes …
A Review of Extracellular Vesicles in COVID‐19 Diagnosis, Treatment, and Prevention
P Su, Y Wu, F Xie, Q Zheng, L Chen, Z Liu… - Advanced …, 2023 - Wiley Online Library
The 2019 novel coronavirus disease (COVID‐19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is ongoing, and has necessitated …
respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is ongoing, and has necessitated …
SARS-CoV-2 papain-like protease (PLpro) inhibitory and antiviral activity of small molecule derivatives for drug leads
We report here the synthesis and biological evaluation of a series of small molecule SARS-
CoV-2 PLpro inhibitors. We compared the activity of selected compounds in both SARS-CoV …
CoV-2 PLpro inhibitors. We compared the activity of selected compounds in both SARS-CoV …
Synthesis, Optimization, and Structure–Activity Relationships of Imidazo[1,2-a]pyrimidines as Inhibitors of Group 2 Influenza A Viruses
S Alqarni, L Cooper, J Galvan Achi, R Bott… - Journal of medicinal …, 2022 - ACS Publications
The influenza A virus (IAV) is a highly contagious virus that causes pandemics and seasonal
epidemics, which are major public health issues. Current anti-influenza therapeutics are …
epidemics, which are major public health issues. Current anti-influenza therapeutics are …
Silver N-heterocyclic carbene complexes are potent uncompetitive inhibitors of the papain-like protease with antiviral activity against SARS-CoV-2
M Gil-Moles, C O'Beirne, IV Esarev… - RSC Medicinal …, 2023 - pubs.rsc.org
The ongoing SARS-CoV-2 pandemic has caused a high demand for novel innovative
antiviral drug candidates. Despite promising results, metal complexes have been relatively …
antiviral drug candidates. Despite promising results, metal complexes have been relatively …
Identification of Cysteine 270 as a Novel Site for Allosteric Modulators of SARS‐CoV‐2 Papain‐Like Protease
The coronavirus papain‐like protease (PLpro) plays an important role in the proteolytic
processing of viral polyproteins and the dysregulation of the host immune response …
processing of viral polyproteins and the dysregulation of the host immune response …
Drug-repurposing screening identified tropifexor as a SARS-CoV-2 papain-like protease inhibitor
The global COVID-19 pandemic underscores the dire need for effective antivirals.
Encouraging progress has been made in developing small-molecule inhibitors targeting the …
Encouraging progress has been made in developing small-molecule inhibitors targeting the …
Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2
BC Sanders, S Pokhrel, AD Labbe, II Mathews… - Nature …, 2023 - nature.com
Direct-acting antivirals are needed to combat coronavirus disease 2019 (COVID-19), which
is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The papain …
is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The papain …
A Patent Review on SARS Coronavirus Papain‐Like Protease (PLpro) Inhibitors
CS Brian Chia, S Pheng Lim - ChemMedChem, 2023 - Wiley Online Library
The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic is an
unprecedented global health emergency causing more than 6.6 million fatalities by 31 …
unprecedented global health emergency causing more than 6.6 million fatalities by 31 …
Pyronaridine protects against SARS-CoV-2 infection in mouse
There are currently relatively few small-molecule antiviral drugs that are either approved or
emergency-approved for use against severe acute respiratory coronavirus 2 (SARS-CoV-2) …
emergency-approved for use against severe acute respiratory coronavirus 2 (SARS-CoV-2) …