M pro main protease takes an essential role in the Sars-Cov-2 viral life cycle by releasing
the individual protein from the single poly-peptide chain via proteolytic cleavage in the …

Objectives We performed a virtual screening of olive secoiridoids of the OliveNet TM library
to predict SARS-CoV-2 PLpro inhibition. Benchmarked molecular docking protocol that …

Since the outbreak of SARS-CoV-2, numerous compounds against COVID-19 have been
derived by computer-aided drug design (CADD) studies. They are valuable resources for the …

Papain-like protease (PLpro) is an attractive drug target for SARS-CoV-2 because it is
essential for viral replication, cleaving viral poly-proteins pp1a and pp1ab, and has de …

Although vaccines are obviously mitigating the COVID-19 pandemic diffusion, efficient
complementary antiviral agents are urgently needed to combat SARS-CoV-2. The viral …

Essential oils and aromatic extracts (oleoresins, absolutes, concretes, resinoids) are often
used as food flavorings and constituents of fragrance compositions. The flavor and fragrance …

Abstract Corona Virus Disease 2019 (COVID-19), caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), poses a serious threat to human health and life …

The two SARS‐CoV‐2 proteases, ie the main protease (Mpro) and the papain‐like protease
(PLpro), which hydrolyze the viral polypeptide chain giving functional non‐structural …

The pandemic caused by the coronavirus SARS-CoV-2 led to a global crisis in the world
healthcare system. Despite some progress in the creation of antiviral vaccines and mass …

Coronaviruses in general are a zoonotic pathogen with significant cross-species
transmission. They are widely distributed in nature and have recently become a major threat …