The COVID-19 pandemic has given a strong impetus to the search for antivirals active on
SARS-associated coronaviruses. Over these years, numerous vaccines have been …

Papain-like protease (PLpro) is a promising therapeutic target against SARS-CoV-2, but its
restricted S1/S2 subsites pose an obstacle in developing active site-directed inhibitors. We …

DNA-encoded library (DEL) technology is gaining attention for its rapid construction and
deconvolution capabilities. Our study explored a novel strategy using rational DELs tailored …

The continuous emergence of SARS-CoV-2 variants caused the persistence of the COVID-
19 epidemic and challenged the effectiveness of the existing vaccines. The viral proteases …

A non-structural SARS-CoV-2 protein, PLpro, is involved in post-translational modifications
in cells, allowing the evasion of antiviral immune response mechanisms. In this study …

Middle East respiratory syndrome coronavirus (MERS-CoV), belonging to the
betacoronavirus genus can cause severe respiratory illnesses, accompanied by pneumonia …

Chalcone is an interesting scaffold found in the structure of many naturally occurring
molecules. Medicinal chemists are commonly interested in designing new chalcone‐based …

Abstract SARS-CoV-2's papain-like protease (PLpro) interaction with ligands has recently
been explored with a myriad of crystal structures. We used molecular dynamics (MD) …

examples of medicinal chemistry approaches to develop smallmolecule drugs for the
treatment of SARS-CoV-2 infection. Two years into the COVID-19 pandemic, SARS-CoV-2 …

Nirmatrelvir (PF-07321332), a first-in-class inhibitor of the severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2) main protease (Mpro), was developed by Pfizer …