Combining computational and experimental evidence on the activity of antimalarial drugs on papain‐like protease of SARS‐CoV‐2: A repurposing study
The development of inhibitors that target the papain‐like protease (PLpro) has the potential
to counteract the spread of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV …
to counteract the spread of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV …
Studies on the selectivity of the SARS-CoV-2 papain-like protease reveal the importance of the P2′ proline of the viral polyprotein
The SARS-CoV-2 papain-like protease (PLpro) is an antiviral drug target that catalyzes the
hydrolysis of the viral polyproteins pp1a/1ab, so releasing the non-structural proteins (nsps) …
hydrolysis of the viral polyproteins pp1a/1ab, so releasing the non-structural proteins (nsps) …
SARS-COV-2 coronavirus papain-like protease PLpro as an antiviral target for inhibitors of active site and protein–protein interactions
PV Ershov, EO Yablokov, YV Mezentsev, GN Chuev… - Biophysics, 2022 - Springer
The papain-like protease PLpro of the SARS-CoV-2 coronavirus is a multifunctional enzyme
that catalyzes the proteolytic processing of two viral polyproteins, pp1a and pp1ab. PLpro …
that catalyzes the proteolytic processing of two viral polyproteins, pp1a and pp1ab. PLpro …
In vitro metabolic characterization of the SARS-CoV-2 papain-like protease inhibitors GRL0617 and HY-17542
The SARS-CoV-2 pandemic requires a new therapeutic target for viral infection, and papain-
like protease (Plpro) has been suggested as a druggable target. This in-vitro study was …
like protease (Plpro) has been suggested as a druggable target. This in-vitro study was …
SAR based review on diverse heterocyclic compounds with various potential molecular targets in the fight against Covid-19: a medicinal chemist perspective
A Madan, M Garg, G Satija, B Sharma… - Current Topics in …, 2023 - ingentaconnect.com
Coronavirus disease (COVID-19) was reported to be transmitted from bats to humans and,
became a pandemic in 2020. COVID-19 is responsible for millions of deaths worldwide and …
became a pandemic in 2020. COVID-19 is responsible for millions of deaths worldwide and …
Discovery of new non-covalent and covalent inhibitors targeting SARS-CoV-2 papain-like protease and main protease
W Liu, J Wang, S Wang, K Yue, Y Hu, X Liu, L Wang… - Bioorganic …, 2023 - Elsevier
Abstract Global coronavirus disease 2019 (COVID-19) pandemic still threatens human
health and public safety, and the development of effective antiviral agent is urgently needed …
health and public safety, and the development of effective antiviral agent is urgently needed …
Structure-Based Design of Potent Peptidomimetic Inhibitors Covalently Targeting SARS-CoV-2 Papain-like Protease
Q Wang, G Chen, J He, J Li, M Xiong, H Su… - International Journal of …, 2023 - mdpi.com
The papain-like protease (PLpro) of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) plays a critical role in the proteolytic processing of viral polyproteins and the …
(SARS-CoV-2) plays a critical role in the proteolytic processing of viral polyproteins and the …
Allosteric Inhibitors of the SARS-COV-2 Papain-like Protease Domain Induce Proteasomal Degradation of Its Parent Protein NSP3
PE Cockram, BT Walters, A Lictao… - ACS Chemical …, 2023 - ACS Publications
The papain-like protease of SARS-COV-2 is essential for viral replication and pathogenesis.
Its location within a much larger multifunctional protein, NSP3, makes it an ideal candidate …
Its location within a much larger multifunctional protein, NSP3, makes it an ideal candidate …
Progress in SARS-CoV-2, diagnostic and clinical treatment of COVID-19
Y Li, SM Lu, JL Wang, HP Yao, LG Liang - Heliyon, 2024 - cell.com
Abstract Background Corona Virus Disease 2019 (COVID-19) is a global pandemic novel
coronavirus infection disease caused by Severe acute respiratory syndrome Coronavirus 2 …
coronavirus infection disease caused by Severe acute respiratory syndrome Coronavirus 2 …
Design, Synthesis, and Biological Evaluation of 1, 2, 4-Oxadiazole Derivatives Containing an Aryl Carboxylic Acid Moiety as Potent Sarbecovirus Papain-like Protease …
B Qin, C Wu, B Zhao, G Li, B Wang, M Ou… - Journal of Medicinal …, 2024 - ACS Publications
Papain-like protease (PLpro) is a promising therapeutic target for its pivotal role in the life
cycle of SARS-CoV-2. A series of 1, 2, 4-oxadiazole derivatives was designed and …
cycle of SARS-CoV-2. A series of 1, 2, 4-oxadiazole derivatives was designed and …