The papain-like protease (PLpro) plays a critical role in SARS-CoV-2 (SCoV-2)
pathogenesis and is essential for viral replication and for allowing the virus to evade the host …

ABSTRACT SARS-CoV-2 papain-like protease (PLpro) could facilitate viral replication and
host immune evasion by respectively hydrolyzing viral polyprotein and host ubiquitin …

Several viruses are now known to code for deubiquitinating proteases in their genomes.
Ubiquitination is an essential post-translational modification of cellular substrates involved in …

Abstract The SARS-CoV-2 papain-like protease (PL pro) and main protease (M pro) are
nucleophilic cysteine enzymes that catalyze the hydrolysis of the viral polyproteins …

COVID-19 has become a pandemic, and any new drug for treating the disease could save
millions of lives. Several drugs already in use for other diseases and medical conditions are …

From the stem bark of Entandrophragma angolense, six undescribed compounds were
isolated, including seco-tirucallane type triterpenoids, limonoids, and a catechin glucoside …

As the global health crisis due to evolution of mutations in SARS-CoV-2 continues, it is
important to develop several effective antivirals to control the disease. Targeting papain-like …

Several investigational nitric oxide donors were originally created to correct vascular
endothelial dysfunction in cardiovascular diseases. These 48 compounds contain an urea …

The papain-like protease (PLpro) found in coronaviruses that can be transmitted from
animals to humans is a critical target in respiratory diseases linked to Severe Acute …

We provide promising computational (in silico) data on phytochemicals (compounds 1–10)
from Arabian Peninsula medicinal plants as strong binders, targeting 3-chymotrypsin-like …