Coronaviruses such as SARS and SARS-CoV-2 have established themselves as a global
health concern after causing an epidemic and a pandemic in the last twenty years …

In late 2019, a new coronavirus (CoV) caused the outbreak of a deadly respiratory disease,
resulting in the COVID-19 pandemic. In view of the ongoing pandemic, there is an …

The papain-like protease (PLpro) of SARS-CoV-2 is essential for viral propagation and,
additionally, dysregulation of the host innate immune system. Using a library of 40 potential …

The viral genome of the SARS-CoV-2 coronavirus, the aetiologic agent of COVID-19,
encodes structural, non-structural, and accessory proteins. Most of these components …

Vaccines and first-generation antiviral therapeutics have provided important protection
against coronavirus disease 2019 (COVID-19) caused by severe acute respiratory …

Abstract Papain-like protease (PLpro), a non-structural protein encoded by SARS-CoV-2, is
an important therapeutic target. Regions 1 and 5 of an existing drug, GRL0617, can be …

There have been relatively few small molecules developed with direct activity against the
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Two existing antimalarial …

In silico identification of potent protein inhibitors commonly requires prediction of a ligand
binding free energy (BFE). Thermodynamics integration (TI) based on molecular dynamics …

SARS‐CoV‐2 cysteine proteases are essential nonstructural proteins due to their role in the
formation of the virus multiple enzyme replication‐transcription complex. As a result, those …

In the global fight against the COVID-19 pandemic caused by the highly transmissible SARS-
CoV-2 virus, the search for potent medications is paramount. With a focused investigation on …