Because of the essential role of PLpro in the regulation of replication and dysregulation of
the host immune sensing, it is considered a therapeutic target for novel drug development …

Background Coronavirus papain-like proteases (PLpros) play a crucial role in virus
replication and the evasion of the host immune response. Infectious bronchitis virus (IBV) …

A series of S-adenosyl-L-homosysteine (SAH) analogs, with modification in the base and
sugar moiety, have been designed, synthesized and screened as nsp14 and PLpro …

The use of computer simulation methods has become an indispensable component in
identifying drugs against the SARS-CoV-2 coronavirus. There is a huge body of literature on …

Developing novel antiviral drugs against the SARS-CoV-2 virus and COVID-19 disease is
imperative as the vaccines may not offer absolute protection. PLpro plays a crucial role in …

The global coronavirus disease 2019 (COVID-19) pandemic persists, with the ongoing
mutation of the virus. Consequently, the development of inhibitors with diverse binding …

Mitigation of the activity of the main protease (Mpro) and papain-like protease (PLpro) of
SARS CoV-2 has direct implications in combating the ongoing deadly COVID-19 pandemic …

Papain-like protease (PLpro) is critical to COVID-19 infection. Therefore, it is a significant
target protein for drug development. We virtually screened a 26,193 compound library …

Virtual screening with high-performance computers is a powerful and cost-effective
technique in drug discovery. A chemical database is searched to find candidate compounds …

Covalent inhibitors of the papain-like protease (PLpro) from SARS-CoV-2 have great
potential as antivirals, but their non-specific reactivity with thiols has limited their …