The dialyzer is the core element in the hemodialysis treatment of patients with end-stage
kidney disease (ESKD). During hemodialysis treatment, the dialyzer replaces the function of …

Individuals afflicted with advanced kidney dysfunction who require dialysis for medical
management exhibit different degrees of native kidney function, called residual kidney …

Patients on hemodialysis show dysregulated immunity, basal hyperinflammation and a
marked vulnerability to COVID-19. We evaluated the immune profile in COVID-19 …

Loss of vitamin C, especially in conjunction with an inadequate supply, can lead to
decreased plasma concentrations of vitamin C. This in turn can lead to overt or subclinical …

Continuous renal replacement therapy (CRRT) is widely used for treating critically-ill
patients in the emergency department in China. Anticoagulant therapy is needed to prevent …

Critically ill COVID-19 patients start developing single respiratory organ failure that often
evolves into multiorgan failure. Understanding the immune mechanisms in severe forms of …

Patients on dialysis have dysfunctions of innate and adaptive immune system responses.
The transcriptional factor IRF8 (interferon regulatory factor 8) is primarily expressed in …

Uremia-induced systemic inflammation is partly caused by the dissemination of microbial
molecules such as lipopolysaccharide and bacterial double-stranded DNA from leaked gut …

Background: Uremic toxins are associated with immune dysfunction and inflammation. The
inadequate removal by hemodialysis (HD) of serum free light chains (FLCs) determines their …

Blood purification represents a treatment option for sepsis, improving inflammation and the
hyper-activated immune system. This study investigates the binding efficacy of Seraph®-100 …