The human proteome contains approximately 20,000 proteins, and it is estimated that more
than 600 of them are functionally important for various types of cancers, including nearly 400 …

Protein–protein interactions (PPIs) have pivotal roles in life processes. The studies showed
that aberrant PPIs are associated with various diseases, including cancer, infectious …

Aberrancy in cell cycle progression is one of the fundamental mechanisms underlying
tumorigenesis, making regulators of the cell cycle machinery rational anticancer therapeutic …

Cullin-RING ubiquitin ligases (CRLs) are dynamic modular platforms that regulate myriad
biological processes through target-specific ubiquitylation. Our knowledge of this system …

Cell cycle progression is a tightly regulated process by which DNA replicates and cell
reproduces. The major driving force underlying cell cycle progression is the sequential …

Ubiquitination is crucial for a plethora of physiological processes, including cell survival and
differentiation and innate and adaptive immunity. In recent years, considerable progress has …

Lysine acetylation is a conserved protein post-translational modification that links acetyl-
coenzyme A metabolism and cellular signalling. Recent advances in the identification and …

Efficient S phase entry is essential for development, tissue repair, and immune defences.
However, hyperactive or expedited S phase entry causes replication stress, DNA damage …

Eukaryotic cell biology depends on cullin–RING E3 ligase (CRL)-catalysed protein
ubiquitylation, which is tightly controlled by the modification of cullin with the ubiquitin-like …

Vitexin and isovitexin are active components of many traditional Chinese medicines, and
were found in various medicinal plants. Vitexin (apigenin-8-C-glucoside) has recently …