In the last decade, the ubiquitin–proteasome system has emerged as a valid target for the
development of novel therapeutics. E3 ubiquitin ligases are particularly attractive targets …

Toll-like receptor (TLR) signaling activates the inhibitor of transcription factor NF-κB (IκB)
kinase (IKK) complex, which governs NF-κB-mediated transcription during inflammation. The …

The ubiquitin-proteasome system plays a pivotal role in the sequence of events leading to
cell division known as the cell cycle. Not only does ubiquitin-mediated proteolysis constitute …

DEPTOR, an inhibitor of mTORC1 and mTORC2, is degraded via ubiquitin-proteasome
pathway by an unknown E3 ubiquitin ligase. Here we report that DEPTOR is a physiological …

Abstract The sirtuins (SIRT 1–7) comprise a family of NAD+-dependent protein-modifying
enzymes with activities in lysine deacetylation, adenosinediphospho (ADP)-ribosylation …

Dysregulation of YAP localization and activity is associated with pathological conditions
such as cancer. Although activation of the Hippo phosphorylation cascade is known to …

p21WAF1/CIP1 is a broad-acting cyclin-dependent kinase inhibitor. Its stability is essential
for proper cell-cycle progression and cell fate decision. Ubiquitylation by the multiple E3 …

The identification of ubiquitin E3 ligase substrates has been challenging, due in part to low-
affinity, transient interactions, the rapid degradation of targets and the inability to identify …

The ubiquitin‐proteasome system (UPS) is a complex process that regulates protein stability
and activity by the sequential actions of E1, E2 and E3 enzymes to influence diverse aspects …

Since its discovery forty years ago, protein ubiquitination has been an ever-expanding field.
Virtually all biological processes are controlled by the post-translational conjugation of …