The activities of both mTORC1 and mTORC2 are negatively regulated by their endogenous
inhibitor, DEPTOR. As such, the abundance of DEPTOR is a critical determinant in the …

Accurate control of the number of centrosomes, the major microtubule-organizing centers of
animal cells, is critical for the maintenance of genome integrity. Abnormalities in centrosome …

Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …

Hepatocellular carcinoma (HCC) is characterized by a poor prognosis and is one of the
leading causes of cancer-related death worldwide. Simvastatin, an HMG-CoA reductase …

Posttranslational neddylation of cullins in the Cullin-Ring E3 ligase (CRL) complexes is
needed for proteolytic degradation of CRL substrates, whose accumulation induces cell …

Since the discovery of the ubiquitin system and the description of its important role in the
degradation of proteins, many studies have shown the importance of ubiquitin-specific …

Mcl-1 is an anti-apoptotic protein of the Bcl-2 family that is essential for the survival of
multiple cell lineages and that is highly amplified in human cancer. Under physiological …

SIRT3 is a member of the Sir2 family of NAD+-dependent protein deacetylases that
promotes longevity in many organisms. The processed short form of SIRT3 is a well …

Many long noncoding RNAs (lncRNAs) are reported to be dysregulated in human cancers
and play critical roles in tumor development and progression. Furthermore, it has been …

In the ubiquitin proteasome system, the E3 ligase SCF-Skp2 and its accessory protein, Cks1,
promote proliferation largely by inducing the degradation of the CDK inhibitor p27 …