Aberrant Skp2 signaling has been implicated as a driving event in tumorigenesis. Although
the underlying molecular mechanisms remain elusive, cytoplasmic Skp2 correlates with …

In the ubiquitin-proteasome system (UPS), E2 enzymes mediate the conjugation of ubiquitin
to substrates and thereby control protein stability and interactions. The E2 enzyme hCdc34 …

MicroRNAs (miRNAs) control cell cycle progression by targeting the transcripts encoding for
cyclins, CDKs and CDK inhibitors, such as p27 KIP1 (p27). p27 expression is controlled by …

Proteasome-mediated degradation is a common mechanism by which cells renew their
intracellular proteins and maintain protein homeostasis. In this process, the E3 ubiquitin …

Activation of v‐akt murine thymoma viral oncogene homolog (AKT) and Ras pathways is
often implicated in carcinogenesis. However, the oncogenic cooperation between these two …

Significance: Maintenance of metabolic homeostasis is critical for cellular and organismal
health. Proper regulation of mitochondrial functions represents a crucial element of overall …

The E3 ligase S-phase kinase-associated protein 2 (Skp2) is overexpressed in human
cancers and correlated with poor prognosis, but its contributions to tumorigenesis and …

Abstract The RhoA GTPase is crucial in numerous biological functions and is linked to
cancer metastasis. However, the understanding of the molecular mechanism responsible for …

Degrons are the elements that are used by E3 ubiquitin ligases to target proteins for
degradation. Most degrons are short linear motifs embedded within the sequences of …

Snail1, a key transcription factor of epithelial–mesenchymal transition (EMT), is subjected to
ubiquitination and degradation, but the mechanism by which Snail1 is stabilized in tumours …