Transcellular nanoalignment of synaptic function
At each of the brain's vast number of synapses, the presynaptic nerve terminal, synaptic cleft,
and postsynaptic specialization form a transcellular unit to enable efficient transmission of …
and postsynaptic specialization form a transcellular unit to enable efficient transmission of …
Sensory processing at ribbon synapses in the retina and the cochlea
T Moser, CP Grabner, F Schmitz - Physiological reviews, 2020 - journals.physiology.org
In recent years, sensory neuroscientists have made major efforts to dissect the structure and
function of ribbon synapses which process sensory information in the eye and ear. This …
function of ribbon synapses which process sensory information in the eye and ear. This …
Revealing nanostructures in brain tissue via protein decrowding by iterative expansion microscopy
Many crowded biomolecular structures in cells and tissues are inaccessible to labelling
antibodies. To understand how proteins within these structures are arranged with nanoscale …
antibodies. To understand how proteins within these structures are arranged with nanoscale …
Four-repeat tauopathies
TW Roesler, AT Marvian, M Brendel… - Progress in …, 2019 - Elsevier
Tau is a microtubule-associated protein with versatile functions in the dynamic assembly of
the neuronal cytoskeleton. Four-repeat (4R-) tauopathies are a group of neurodegenerative …
the neuronal cytoskeleton. Four-repeat (4R-) tauopathies are a group of neurodegenerative …
Bassoon controls presynaptic autophagy through Atg5
ND Okerlund, K Schneider, S Leal-Ortiz… - Neuron, 2017 - cell.com
Mechanisms regulating the surveillance and clearance of synaptic proteins are not well
understood. Intriguingly, the loss of the presynaptic active zone proteins Piccolo and …
understood. Intriguingly, the loss of the presynaptic active zone proteins Piccolo and …
Role of bassoon and piccolo in assembly and molecular organization of the active zone
ED Gundelfinger, C Reissner… - Frontiers in synaptic …, 2016 - frontiersin.org
Bassoon and Piccolo are two very large scaffolding proteins of the cytomatrix assembled at
the active zone (CAZ) where neurotransmitter is released. They share regions of high …
the active zone (CAZ) where neurotransmitter is released. They share regions of high …
Super-resolving microscopy in neuroscience
Fluorescence imaging techniques play a pivotal role in our understanding of the nervous
system. The emergence of various super-resolution microscopy methods and specialized …
system. The emergence of various super-resolution microscopy methods and specialized …
How to make an active zone: unexpected universal functional redundancy between RIMs and RIM-BPs
C Acuna, X Liu, TC Südhof - Neuron, 2016 - cell.com
RIMs and RIM-binding proteins (RBPs) are evolutionary conserved multidomain proteins of
presynaptic active zones that are known to recruit Ca 2+ channels; in addition, RIMs perform …
presynaptic active zones that are known to recruit Ca 2+ channels; in addition, RIMs perform …
Fusion competent synaptic vesicles persist upon active zone disruption and loss of vesicle docking
In a nerve terminal, synaptic vesicle docking and release are restricted to an active zone.
The active zone is a protein scaffold that is attached to the presynaptic plasma membrane …
The active zone is a protein scaffold that is attached to the presynaptic plasma membrane …
Prenatal immune activation causes hippocampal synaptic deficits in the absence of overt microglia anomalies
S Giovanoli, U Weber-Stadlbauer… - Brain, behavior, and …, 2016 - Elsevier
Prenatal exposure to infectious or inflammatory insults can increase the risk of developing
neuropsychiatric disorder in later life, including schizophrenia, bipolar disorder, and autism …
neuropsychiatric disorder in later life, including schizophrenia, bipolar disorder, and autism …