Microvascular endothelial cells in the kidney have been a neglected cell type in sepsis-
induced acute kidney injury (sepsis-AKI) research; yet, they offer tremendous potential as …

Oxygen is essential for the maintenance of the body. Living organisms have evolved
systems to secure an oxygen environment to be proper. Hypoxia-inducible factor (HIF) plays …

Glomerular filtration rate (GFR) is acutely increased following a high-protein meal or
systemic infusion of amino acids. The mechanisms underlying this renal functional response …

Sepsis is the leading cause of acute kidney injury (AKI) and leads to increased morbidity
and mortality in intensive care units. Current treatments for septic AKI are largely supportive …

Sepsis is a heterogenous and highly complex clinical syndrome, which is caused by
infectious or noninfectious factors. Acute kidney injury (AKI) is one of the most common and …

Sepsis-associated AKI is a life-threatening complication that is associated with high
morbidity and mortality in patients who are critically ill. Although it is clear early supportive …

Objectives: Oxidative stress appears to initiate organ failure in sepsis, justifying treatment
with antioxidants such as vitamin C at megadoses. We have therefore investigated the safety …

Acute kidney injury (AKI) is common in the critically ill. Inadequate renal medullary tissue
oxygenation has been linked to its pathogenesis. Moreover, renal medullary tissue hypoxia …

Background Acute kidney injury (AKI) is a common complication in critically ill patients with
sepsis and is often associated with a poor prognosis. We aimed to construct and validate an …

Sepsis induced by bacteria or viruses can result in multiorgan dysfunction, which is a major
cause of death in intensive care units. Current treatments are only supportive, and there are …