Isatin derivatives as broad-spectrum antiviral agents: the current landscape
T Elsaman, MS Mohamed, EM Eltayib… - Medicinal Chemistry …, 2022 - Springer
In recent decades, several viruses have resulted in large outbreaks with serious health,
economic and social consequences. The current unprecedented outbreak of the new …
economic and social consequences. The current unprecedented outbreak of the new …
Can limonene be a possible candidate for evaluation as an agent or adjuvant against infection, immunity, and inflammation in COVID-19?
Abstract Coronavirus disease (COVID-19) caused by novel severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is an ongoing pandemic and presents a public …
syndrome coronavirus 2 (SARS-CoV-2) is an ongoing pandemic and presents a public …
Kobophenol A inhibits binding of host ACE2 receptor with spike RBD domain of SARS-CoV-2, a lead compound for blocking COVID-19
In the search for inhibitors of COVID-19, we have targeted the interaction between the
human angiotensin-converting enzyme 2 (ACE2) receptor and the spike receptor binding …
human angiotensin-converting enzyme 2 (ACE2) receptor and the spike receptor binding …
Development of novel indolin-2-one derivative incorporating thiazole moiety as DHFR and quorum sensing inhibitors: Synthesis, antimicrobial, and antibiofilm …
AY Alzahrani, YA Ammar, M Abu-Elghait, MA Salem… - Bioorganic …, 2022 - Elsevier
Nowadays, it's imperative to develop novel antimicrobial agents active against both drug-
sensitive and drug-resistant bacterial infections with favorable profiles as high efficacy, low …
sensitive and drug-resistant bacterial infections with favorable profiles as high efficacy, low …
Newly synthesized series of oxoindole–oxadiazole conjugates as potential anti-SARS-CoV-2 agents: In silico and in vitro studies
In this study, a series of 1, 3, 4-oxadiazoles carrying the isatin moiety (IVa–g) as anti-SARS-
CoV-2 agents were designed and synthesized. Molecular docking of the compounds (IVa–g) …
CoV-2 agents were designed and synthesized. Molecular docking of the compounds (IVa–g) …
Synthesis, structural characterization, DFT calculations, and molecular docking of a novel quinoline derivative
A novel quinoline derivative,(E)-N-phenyl-4-((quinoli-4-ylmethylene) amino) aniline (PQYA),
was synthesized using a previously reported approach with 80% yield. Single X-ray …
was synthesized using a previously reported approach with 80% yield. Single X-ray …
Design, synthesis, and molecular dynamics simulation studies of quinoline derivatives as protease inhibitors against SARS-CoV-2
A new series of quinoline derivatives has been designed and synthesized as probable
protease inhibitors (PIs) against severe acute respiratory syndrome coronavirus 2. In silico …
protease inhibitors (PIs) against severe acute respiratory syndrome coronavirus 2. In silico …
Design and various in silico studies of the novel curcumin derivatives as potential candidates against COVID-19-associated main enzymes
The novel coronavirus disease (COVID-19) is a highly contagious disease caused by the
SARS-CoV-2 virus, leading severe acute respiratory syndrome in patients. Although various …
SARS-CoV-2 virus, leading severe acute respiratory syndrome in patients. Although various …
Design, synthesis and in vitro evaluation of spirooxindole-based phenylsulfonyl moiety as a candidate anti-SAR-CoV-2 and MERS-CoV-2 with the Implementation of …
The search for an effective anti-viral to inhibit COVID-19 is a challenge for the specialized
scientific research community. This work investigated the anti-coronavirus activity for …
scientific research community. This work investigated the anti-coronavirus activity for …
AI-Driven Discovery of SARS-CoV-2 Main Protease Fragment-like Inhibitors with Antiviral Activity In Vitro
LC Saramago, MV Santana, BF Gomes… - Journal of Chemical …, 2023 - ACS Publications
SARS-CoV-2 is the causative agent of COVID-19 and is responsible for the current global
pandemic. The viral genome contains 5 major open reading frames of which the largest …
pandemic. The viral genome contains 5 major open reading frames of which the largest …