Simple Summary Integrins, a superfamily of cell adhesion receptors, were extensively
investigated as therapeutic targets over the last decades, motivated by their multiple …

Selective and targeted delivery of drugs to tumors is a major challenge for an effective
cancer therapy and also to overcome the side-effects associated with current treatments …

Molecular imaging is an emerging field that integrates advanced imaging technology with
cellular and molecular biology. It can realize noninvasive and real time visualization …

Purpose: The study was undertaken to develop and evaluate the potential of an integrin
αvβ6-binding peptide (αvβ6-BP) for noninvasive imaging of a diverse range of malignancies …

Purpose The RGD-integrin, αvβ6, plays a role in the pathogenesis of pulmonary fibrosis
through activation of transforming growth factor beta (TGFβ). This study sought to quantify …

Noninvasive determination of integrin expression has become an interesting approach in
nuclear medicine. Since the discovery of the first 18F‐labeled cyclic RGD peptide as …

Several minimally invasive image guided tumor ablation techniques have been added to the
treatment spectrum for locally advanced pancreatic cancer (LAPC). Irreversible …

Purpose The purpose of this study was to identify suitable molecular targets for tumor-
specific imaging of pancreatic adenocarcinoma. Procedures The expression of eight …

Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis. To improve outcomes,
there is a critical need for improved tools for detection, accurate staging, and resectability …

Targets play an indispensable and pivotal role in the development of radiopharmaceuticals.
However, the initial stages of drug discovery projects are often plagued by frequent failures …