Widespread exon skipping triggers degradation by nuclear RNA surveillance in fission yeast
Exon skipping is considered a principal mechanism by which eukaryotic cells expand their
transcriptome and proteome repertoires, creating different splice variants with distinct …
transcriptome and proteome repertoires, creating different splice variants with distinct …
[HTML][HTML] Transcriptome maps of general eukaryotic RNA degradation factors
S Sohrabi-Jahromi, KB Hofmann, A Boltendahl, C Roth… - Elife, 2019 - elifesciences.org
RNA degradation pathways enable RNA processing, the regulation of RNA levels, and the
surveillance of aberrant or poorly functional RNAs in cells. Here we provide transcriptome …
surveillance of aberrant or poorly functional RNAs in cells. Here we provide transcriptome …
Altered rRNA processing disrupts nuclear RNA homeostasis via competition for the poly (A)-binding protein Nab2
RNA-binding proteins (RBPs) are key mediators of RNA metabolism. Whereas some RBPs
exhibit narrow transcript specificity, others function broadly across both coding and non …
exhibit narrow transcript specificity, others function broadly across both coding and non …
[HTML][HTML] A ZTF-7/RPS-2 complex mediates the cold-warm response in C. elegans
T Xu, S Liao, M Huang, C Zhu, X Huang, Q Jin… - PLoS …, 2023 - journals.plos.org
Temperature greatly affects numerous biological processes in all organisms. How
multicellular organisms respond to and are impacted by hypothermic stress remains elusive …
multicellular organisms respond to and are impacted by hypothermic stress remains elusive …
The Mtr4 ratchet helix and arch domain both function to promote RNA unwinding
LL Taylor, RN Jackson, M Rexhepaj… - Nucleic acids …, 2014 - academic.oup.com
Mtr4 is a conserved Ski2-like RNA helicase and a subunit of the TRAMP complex that
activates exosome-mediated 3′-5′ turnover in nuclear RNA surveillance and processing …
activates exosome-mediated 3′-5′ turnover in nuclear RNA surveillance and processing …
Genetic and genomic studies of pathogenic EXOSC2 mutations in the newly described disease SHRF implicate the autophagy pathway in disease pathogenesis
Missense mutations in the RNA exosome component exosome component 2 (EXOSC2),
also known as ribosomal RNA-processing protein 4 (RRP4), were recently identified in two …
also known as ribosomal RNA-processing protein 4 (RRP4), were recently identified in two …
Targeting the nuclear RNA exosome: poly (A) binding proteins enter the stage
N Meola, TH Jensen - RNA biology, 2017 - Taylor & Francis
Centrally positioned in nuclear RNA metabolism, the exosome deals with virtually all
transcript types. This 3′–5′ exo-and endo-nucleolytic degradation machine is guided to its …
transcript types. This 3′–5′ exo-and endo-nucleolytic degradation machine is guided to its …
[HTML][HTML] The interplay between transcription and mRNA degradation in Saccharomyces cerevisiae
The cellular transcriptome is shaped by both the rates of mRNA synthesis in the nucleus and
mRNA degradation in the cytoplasm under a specified condition. The last decade witnessed …
mRNA degradation in the cytoplasm under a specified condition. The last decade witnessed …
Altered RNA processing and export lead to retention of mRNAs near transcription sites and nuclear pore complexes or within the nucleolus
B Paul, B Montpetit - Molecular biology of the cell, 2016 - Am Soc Cell Biol
Many protein factors are required for mRNA biogenesis and nuclear export, which are
central to the eukaryotic gene expression program. It is unclear, however, whether all factors …
central to the eukaryotic gene expression program. It is unclear, however, whether all factors …
Mtr4 RNA helicase structures and interactions
KJ Olsen, SJ Johnson - Biological chemistry, 2021 - degruyter.com
Mtr4 is a Ski2-like RNA helicase that plays a central role in RNA surveillance and
degradation pathways as an activator of the RNA exosome. Multiple crystallographic and …
degradation pathways as an activator of the RNA exosome. Multiple crystallographic and …