Importance of including non-European populations in large human genetic studies to enhance precision medicine
One goal of genomic medicine is to uncover an individual's genetic risk for disease, which
generally requires data connecting genotype to phenotype, as done in genome-wide …
generally requires data connecting genotype to phenotype, as done in genome-wide …
Genome-wide association studies of cardiovascular disease
R Walsh, SJ Jurgens, J Erdmann… - Physiological …, 2023 - journals.physiology.org
Genome-wide association studies (GWAS) aim to identify common genetic variants that are
associated with traits and diseases. Since 2005, more than 5,000 GWAS have been …
associated with traits and diseases. Since 2005, more than 5,000 GWAS have been …
Regional and sex differences in the prevalence and awareness of hypertension: an H3Africa AWI-Gen study across 6 sites in sub-Saharan Africa
Background There is a high prevalence of hypertension and related cardiovascular
diseases in sub-Saharan Africa, yet few large studies exploring hypertension in Africa are …
diseases in sub-Saharan Africa, yet few large studies exploring hypertension in Africa are …
Extracting research-quality phenotypes from electronic health records to support precision medicine
The convergence of two rapidly developing technologies-high-throughput genotyping and
electronic health records (EHRs)-gives scientists an unprecedented opportunity to utilize …
electronic health records (EHRs)-gives scientists an unprecedented opportunity to utilize …
Genetics of schizophrenia in the South African Xhosa
Africa, the ancestral home of all modern humans, is the most informative continent for
understanding the human genome and its contribution to complex disease. To better …
understanding the human genome and its contribution to complex disease. To better …
Prevalence of hypertension in Ghanaian society: a systematic review, meta-analysis, and GRADE assessment
Background Hypertension has become an important public health concern in the developing
world owing to rising prevalence and its adverse impact on ailing health systems. Despite …
world owing to rising prevalence and its adverse impact on ailing health systems. Despite …
Qatar genome: Insights on genomics from the Middle East
H Mbarek, G Devadoss Gandhi, S Selvaraj… - Human …, 2022 - Wiley Online Library
Despite recent biomedical breakthroughs and large genomic studies growing momentum,
the Middle Eastern population, home to over 400 million people, is underrepresented in the …
the Middle Eastern population, home to over 400 million people, is underrepresented in the …
Admixture into and within sub-Saharan Africa
Similarity between two individuals in the combination of genetic markers along their
chromosomes indicates shared ancestry and can be used to identify historical connections …
chromosomes indicates shared ancestry and can be used to identify historical connections …
Machine learning research trends in Africa: a 30 years overview with bibliometric analysis review
AE Ezugwu, ON Oyelade, AM Ikotun… - … Methods in Engineering, 2023 - Springer
The machine learning (ML) paradigm has gained much popularity today. Its algorithmic
models are employed in every field, such as natural language processing, pattern …
models are employed in every field, such as natural language processing, pattern …
Genomic and environmental risk factors for cardiometabolic diseases in Africa: methods used for Phase 1 of the AWI-Gen population cross-sectional study
There is an alarming tide of cardiovascular and metabolic disease (CMD) sweeping across
Africa. This may be a result of an increasingly urbanized lifestyle characterized by the …
Africa. This may be a result of an increasingly urbanized lifestyle characterized by the …