Importance of including non-European populations in large human genetic studies to enhance precision medicine

D Ju, D Hui, DA Hammond, A Wonkam… - Annual review of …, 2022 - annualreviews.org
One goal of genomic medicine is to uncover an individual's genetic risk for disease, which
generally requires data connecting genotype to phenotype, as done in genome-wide …

Genome-wide association studies of cardiovascular disease

R Walsh, SJ Jurgens, J Erdmann… - Physiological …, 2023 - journals.physiology.org
Genome-wide association studies (GWAS) aim to identify common genetic variants that are
associated with traits and diseases. Since 2005, more than 5,000 GWAS have been …

Regional and sex differences in the prevalence and awareness of hypertension: an H3Africa AWI-Gen study across 6 sites in sub-Saharan Africa

FX Gómez-Olivé, SA Ali, F Made, C Kyobutungi… - Global heart, 2017 - Elsevier
Background There is a high prevalence of hypertension and related cardiovascular
diseases in sub-Saharan Africa, yet few large studies exploring hypertension in Africa are …

Extracting research-quality phenotypes from electronic health records to support precision medicine

WQ Wei, JC Denny - Genome medicine, 2015 - Springer
The convergence of two rapidly developing technologies-high-throughput genotyping and
electronic health records (EHRs)-gives scientists an unprecedented opportunity to utilize …

Genetics of schizophrenia in the South African Xhosa

S Gulsuner, DJ Stein, ES Susser, G Sibeko, A Pretorius… - Science, 2020 - science.org
Africa, the ancestral home of all modern humans, is the most informative continent for
understanding the human genome and its contribution to complex disease. To better …

Prevalence of hypertension in Ghanaian society: a systematic review, meta-analysis, and GRADE assessment

F Atibila, G Hoor, ET Donkoh, AI Wahab, G Kok - Systematic reviews, 2021 - Springer
Background Hypertension has become an important public health concern in the developing
world owing to rising prevalence and its adverse impact on ailing health systems. Despite …

Qatar genome: Insights on genomics from the Middle East

H Mbarek, G Devadoss Gandhi, S Selvaraj… - Human …, 2022 - Wiley Online Library
Despite recent biomedical breakthroughs and large genomic studies growing momentum,
the Middle Eastern population, home to over 400 million people, is underrepresented in the …

Admixture into and within sub-Saharan Africa

GBJ Busby, G Band, Q Si Le, M Jallow, E Bougama… - elife, 2016 - elifesciences.org
Similarity between two individuals in the combination of genetic markers along their
chromosomes indicates shared ancestry and can be used to identify historical connections …

Machine learning research trends in Africa: a 30 years overview with bibliometric analysis review

AE Ezugwu, ON Oyelade, AM Ikotun… - … Methods in Engineering, 2023 - Springer
The machine learning (ML) paradigm has gained much popularity today. Its algorithmic
models are employed in every field, such as natural language processing, pattern …

Genomic and environmental risk factors for cardiometabolic diseases in Africa: methods used for Phase 1 of the AWI-Gen population cross-sectional study

SA Ali, C Soo, G Agongo, M Alberts… - Global health …, 2018 - Taylor & Francis
There is an alarming tide of cardiovascular and metabolic disease (CMD) sweeping across
Africa. This may be a result of an increasingly urbanized lifestyle characterized by the …