Recent revelations that the canonical Wnt signaling pathway promotes postnatal bone
accrual are major advances in our understanding of skeletal biology and bring tremendous …

The cross-regulation of Wnt/β-catenin/Tcf ligands, kinases, and transcription factors with
members of the nuclear receptor (NR) family has emerged as a clinically and …

The Wnt/β-catenin pathway has been implicated in bone cell response to their mechanical
environment. This response is the origin of the mechanism by which bone cells adjust bone …

Introduction Wnt signalling has been implicated in stem cell regulation however its role in
breast cancer stem cell regulation remains unclear. Methods We used a panel of normal and …

Major biological effects of estrogen in the uterus are thought to be primarily mediated by
nuclear estrogen receptors, ERα and ERβ. We show here that estrogen in an ER …

Osteopontin (OPN) is a predominantly secreted extracellular matrix glycophosphoprotein
which binds to alpha v-containing integrins and has an important role in malignant cell …

Estrogen receptors ERα and ERβ, members of the nuclear receptor superfamily, exert
profound effects on the gene expression and biological response programs of their target …

A yeast two-hybrid assay was employed to identify androgen receptor (AR) protein partners
in gonadotropin-releasing hormone neuronal cells. By using an AR deletion construct (AR …

Stem cells are a powerful resource for cell-based transplantation therapies in
osteodegenerative disorders, but before some kinds of stem cells can be applied clinically …

Aromatase inhibitors are the major first-line treatment of estrogen receptor–positive breast
cancer, but resistance to treatment is common. To date, no biomarkers have been validated …