Simulation of the clinical and pathological manifestations of coronavirus disease 2019 (COVID-19) in a golden Syrian hamster model: implications for disease …

JFW Chan, AJ Zhang, S Yuan, VKM Poon… - Clinical infectious …, 2020 - academic.oup.com
Background A physiological small-animal model that resembles COVID-19 with low mortality
is lacking. Methods Molecular docking on the binding between angiotensin-converting …

Rapid asymptomatic transmission of COVID-19 during the incubation period demonstrating strong infectivity in a cluster of youngsters aged 16-23 years outside …

L Huang, X Zhang, X Zhang, Z Wei, L Zhang, J Xu… - Journal of infection, 2020 - Elsevier
Background The outbreak of coronavirus-disease-2019 (COVID-19) has rapidly spread to
many places outside Wuhan. Previous studies on COVID-19 mostly included older …

[HTML][HTML] Racial disparities-associated COVID-19 mortality among minority populations in the US

DJ Alcendor - Journal of clinical medicine, 2020 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a betacoronavirus that
causes the novel coronavirus disease 2019 (COVID-19), is highly transmissible and …

[HTML][HTML] A review of SARS-CoV-2 and the ongoing clinical trials

YF Tu, CS Chien, AA Yarmishyn, YY Lin… - International journal of …, 2020 - mdpi.com
The sudden outbreak of 2019 novel coronavirus (2019-nCoV, later named SARS-CoV-2) in
Wuhan, China, which rapidly grew into a global pandemic, marked the third introduction of a …

Coronavirus infections and immune responses

G Li, Y Fan, Y Lai, T Han, Z Li, P Zhou… - Journal of medical …, 2020 - Wiley Online Library
Coronaviruses (CoVs) are by far the largest group of known positive‐sense RNA viruses
having an extensive range of natural hosts. In the past few decades, newly evolved …

[HTML][HTML] Overview of lethal human coronaviruses

B Chen, EK Tian, B He, L Tian, R Han… - Signal transduction and …, 2020 - nature.com
Coronavirus infections of multiple origins have spread to date worldwide, causing severe
respiratory diseases. Seven coronaviruses that infect humans have been identified: HCoV …

SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: an in silico perspective

AA Elfiky - Journal of Biomolecular Structure and Dynamics, 2021 - Taylor & Francis
New treatment against SARS-CoV-2 now is a must. Nowadays, the world encounters a huge
health crisis by the COVID-19 viral infection. Nucleotide inhibitors gave a lot of promising …

[HTML][HTML] A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster

JFW Chan, S Yuan, KH Kok, KKW To, H Chu, J Yang… - The lancet, 2020 - thelancet.com
Background An ongoing outbreak of pneumonia associated with a novel coronavirus was
reported in Wuhan city, Hubei province, China. Affected patients were geographically linked …

Highly pathogenic coronavirus N protein aggravates lung injury by MASP-2-mediated complement over-activation

T Gao, M Hu, X Zhang, H Li, L Zhu, H Liu, Q Dong… - MedRxiv, 2020 - medrxiv.org
An excessive immune response contributes to SARS-CoV, MERS-CoV and SARS-CoV-2
pathogenesis and lethality, but the mechanism remains unclear. In this study, the N proteins …

Emergence of a novel coronavirus, severe acute respiratory syndrome coronavirus 2: biology and therapeutic options

S Khan, R Siddique, MA Shereen, A Ali… - Journal of clinical …, 2020 - Am Soc Microbiol
The new decade of the 21st century (2020) started with the emergence of a novel
coronavirus known as SARS-CoV-2 that caused an epidemic of coronavirus disease …