Hearing loss and brain plasticity: the hyperactivity phenomenon

B Herrmann, BE Butler - Brain Structure and Function, 2021 - Springer
Many aging adults experience some form of hearing problems that may arise from auditory
peripheral damage. However, it has been increasingly acknowledged that hearing loss is …

[HTML][HTML] Genetic architecture distinguishes tinnitus from hearing loss

RE Clifford, AX Maihofer, C Chatzinakos… - Nature …, 2024 - nature.com
Tinnitus is a heritable, highly prevalent auditory disorder treated by multiple medical
specialties. Previous GWAS indicated high genetic correlations between tinnitus and …

Characterization of anxiety-like behaviors and neural circuitry following chronic moderate noise exposure in mice

X Peng, Y Mao, Y Tai, B Luo, Q Dai… - Environmental …, 2023 - ehp.niehs.nih.gov
Background: Commonly encountered nontraumatic, moderate noise is increasingly
implicated in anxiety; however, the neural substrates underlying this process remain …

[HTML][HTML] Specific brain network predictors of interventions with different mechanisms for tinnitus patients

L Lan, Y Liu, Y Wu, ZG Xu, JJ Xu, JJ Song, R Salvi… - …, 2022 - thelancet.com
Background The aberrant brain network that gives rise to the phantom sound of tinnitus is
believed to determine the effectiveness of tinnitus therapies involving neuromodulation with …

Can GABAkines quiet the noise? The GABAA receptor neurobiology and pharmacology of tinnitus

JM Witkin, A Lippa, JL Smith, JM Cook - Biochemical Pharmacology, 2022 - Elsevier
Tinnitus is a highly prevalent and disabling disorder in which sound is perceived in the
absence of an external auditory energy source. The disorder is complex and can arise from …

Neuroprotection Role of Vitamin C by Upregulating Glutamate Transporter-1 in Auditory Cortex of Noise-Induced Tinnitus Animal Model

W Cao, S Xiong, W Ji, H Wei, F Ma… - ACS Chemical …, 2024 - ACS Publications
Vitamin C (Vc) plays a pivotal role in a series of pathological processes, such as tumors,
immune diseases, and neurological disorders. However, its therapeutic potential for tinnitus …

Differential plasticity in auditory and prefrontal cortices, and cognitive-behavioral deficits following noise-induced hearing loss

KB Wieczerzak, SV Patel, H MacNeil, KE Scott… - Neuroscience, 2021 - Elsevier
Excessive exposure to loud noise causes hearing loss and neural plasticity throughout the
auditory pathway. Recent studies have identified that non-auditory regions, such as the …

Microglial activation in the lateral amygdala promotes anxiety‐like behaviors in mice with chronic moderate noise exposure

X Peng, Y Mao, Y Liu, Q Dai, Y Tai… - CNS Neuroscience …, 2024 - Wiley Online Library
Background Long‐term non‐traumatic noise exposure, such as heavy traffic noise, can elicit
emotional disorders in humans. However, the underlying neural substrate is still poorly …

[HTML][HTML] Characterization of the neural circuitry of the auditory thalamic reticular nucleus and its potential role in salicylate-induced tinnitus

Q Dai, T Qu, G Shen, H Wang - Frontiers in Neuroscience, 2024 - frontiersin.org
Introduction Subjective tinnitus, the perception of sound without an external acoustic source,
is often subsequent to noise-induced hearing loss or ototoxic medications. The condition is …

[HTML][HTML] Application of functional near-infrared spectroscopy (fNIRS) in tinnitus research: contemporary insights and perspectives

H Hu, X Lin, Z Ye, L Fang, H Gao, Q Zhang - Frontiers in Psychology, 2024 - frontiersin.org
Tinnitus, characterized by phantom sound perception, is a highly disruptive condition lacking
clearly effective treatments. Its complex neural mechanisms are not fully elucidated …