[HTML][HTML] Transcription factor CREB3L1 regulates the expression of the sodium/iodide symporter (NIS) in rat thyroid follicular cells

P Di Giusto, M Martín, M Funes Chabán, L Sampieri… - Cells, 2022 - mdpi.com
The transcription factor CREB3L1 is expressed in a wide variety of tissues including
cartilage, pancreas, and bone. It is located in the endoplasmic reticulum and upon …

A Novel SLC5A5 Variant Reveals the Crucial Role of Kinesin Light Chain 2 in Thyroid Hormonogenesis

M Martín, CP Modenutti, ML Gil Rosas… - The Journal of …, 2021 - academic.oup.com
Context Iodide transport defect (ITD)(Online Mendelian Inheritance in Man No. 274400) is
an uncommon cause of dyshormonogenic congenital hypothyroidism due to loss-of-function …

The PDZ protein SCRIB regulates sodium/iodide symporter (NIS) expression at the basolateral plasma membrane

M Martín, L Salleron, V Peyret, RC Geysels… - The FASEB …, 2021 - Wiley Online Library
The sodium/iodide symporter (NIS) expresses at the basolateral plasma membrane of the
thyroid follicular cell and mediates iodide accumulation required for normal thyroid …

An intramolecular ionic interaction linking defective sodium/iodide symporter transport to the plasma membrane and dyshormonogenic congenital hypothyroidism

CE Bernal Barquero, M Martín, RC Geysels, V Peyret… - Thyroid, 2022 - liebertpub.com
Background: The sodium/iodide symporter (NIS) mediates active iodide accumulation in the
thyroid follicular cell. Autosomal recessive iodide transport defect (ITD)-causing loss-of …

[HTML][HTML] Targeted next-generation sequencing of congenital hypothyroidism-causative genes reveals unexpected thyroglobulin gene variants in patients with iodide …

CE Bernal Barquero, RC Geysels, V Jacques… - International Journal of …, 2022 - mdpi.com
Congenital iodide transport defect is an uncommon autosomal recessive disorder caused by
loss-of-function variants in the sodium iodide symporter (NIS)-coding SLC5A5 gene and …

Selenium bioavailability modulates the sensitivity of thyroid cells to iodide excess

R Oglio, C Rodriguez, L Salvarredi, L Rossich… - Chemico-Biological …, 2024 - Elsevier
Introduction Iodide is an essential micronutrient for the synthesis of thyroid hormones and its
imbalance is involved in the origin of different thyroid pathological processes. Selenium (Se) …

Thyroid Stem Cell Speciation—a Major Role for PKC

R Latif, SA Morshed, C McCann, TF Davies - Endocrinology, 2023 - academic.oup.com
Instructive signals that delineate the formation of thyroid follicles by thyrotropin (TSH) in stem
cells are complex. Here, we have examined the role of protein kinase C (PKC) by using a …

TSAb Modulates Microglia M1 Polarization via Activation of the TSHR-Mediated NF-κB Signaling Pathway

Y Liu, H Yang, X Wu, Y Kuang, B Ban, Z Liang… - …, 2023 - karger.com
Introduction: Thyrotropin receptor-stimulating antibody (TSAb) is a pathogenic antibody in
the serum of patients with Graves' disease. The binding of TSAb to thyroid-stimulating …

[PDF][PDF] TSHR Promotes Proliferation and Invasion of Papillary Thyroid Carcinoma By Regulating NF-κB Signal Pathway

X Lin, C Ma, G Zheng, H Sun, X Lin, S Wei, G Wu… - 2022 - scholar.archive.org
Purpose: To investigate the signi cance of TSHR and NF-κB P65 expression difference in
thyroid papillary carcinoma, and to explore how TSHR affects the biological behavior of PTC …

Desarrollo de alternativas diagnósticas para el abordaje molecular de la patología congénita hereditaria de la glándula tiroides

CE Bernal Barquero - rdu.unc.edu.ar
Las hormonas tiroideas juegan un papel crucial en la diferenciación y el desarrollo del
sistema nervioso central. Su deficiencia funcional al nacimiento se conoce como …