Loss and gain of functions mutations in the X-linked MECP2 (methyl-CpG-binding protein 2)
gene are responsible for a set of generally severe neurological disorders that can affect both …

DNA methylation, one of the most well-studied epigenetic modifications, is involved in a
wide spectrum of biological processes. Epigenetic mechanisms control cellular morphology …

Background Identification of genetic causes of central precocious puberty have revealed
epigenetic mechanisms as regulators of human pubertal timing. MECP2, an X-linked gene …

Unscheduled R loops can be a source of genome instability, a hallmark of cancer cells.
Although targeted proteomic approaches and cellular analysis of specific mutants have …

Methyl-CpG-binding protein 2 (MeCP2) is a transcriptional regulator that is highly abundant
in the brain. It binds to methylated genomic DNA to regulate a range of physiological …

Sexual dimorphism has been reported in various human diseases including autoimmune
diseases, neurological diseases, pulmonary arterial hypertension, and some types of …

Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with increased
prevalence and incidence in recent decades. Its etiology remains largely unclear, but it …

CHRFAM7A is a relatively recent and exclusively human gene arising from the partial
duplication of exons 5 to 10 of the α7 neuronal nicotinic acetylcholine receptor subunit (α7 …

A remarkable feature of the brain is its sexual dimorphism. Sexual dimorphism in brain
structure and function is associated with clinical implications documented previously in …

Rett syndrome (RTT) is an X‐linked neurogenetic disorder caused by mutations of the
MECP2 (methyl‐CpG‐binding protein 2) gene. Over two decades of work established …