Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …

Objective The goal of this narrative review is to provide an overview of migraine
pathophysiology, with an emphasis on the role of calcitonin gene‐related peptide (CGRP) …

INTRODUCTION The lung, with its vast surface area, senses and responds to signals in
inhaled air. Aberrant interactions between the lung and the environment underlie many …

The calcitonin/CGRP family of peptides includes calcitonin, α and β CGRP, amylin,
adrenomedullin (AM) and adrenomedullin 2/intermedin (AM2/IMD). Their receptors consist …

Migraine is the second leading cause for disability worldwide and the most common
neurological disorder. It is also three times more common in women; reasons for this sex …

Objective Migraine is a prevalent and disabling neurological disease. Its genesis is poorly
understood, and there remains unmet clinical need. We aimed to identify mechanisms and …

Migraine is a common neurological disorder with a diverse clinical phenotype that
comprises more than just head pain. Premonitory (prodromal) symptoms can start hours to …

A Systems Neuroscience Approach to Migraine Page 1 Neuron Perspective A Systems
Neuroscience Approach to Migraine KC Brennan1,* and Daniela Pietrobon2,3,* 1Department …

The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …

Animal models have provided a growing body of information about the pathophysiology of
headaches and novel therapeutic targets. In recent years, experiments in awake animals …