Emerging roles of SIRT6 in human diseases and its modulators
The biological functions of sirtuin 6 (SIRT6; eg, deacetylation, defatty‐acylation, and mono‐
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …
PI3K signaling in neurons: a central node for the control of multiple functions
K Sánchez-Alegría, M Flores-León… - International journal of …, 2018 - mdpi.com
Phosphoinositide 3-kinase (PI3K) signaling contributes to a variety of processes, mediating
many aspects of cellular function, including nutrient uptake, anabolic reactions, cell growth …
many aspects of cellular function, including nutrient uptake, anabolic reactions, cell growth …
Conditional BDNF delivery from astrocytes rescues memory deficits, spine density, and synaptic properties in the 5xFAD mouse model of Alzheimer disease
B de Pins, C Cifuentes-Díaz, AT Farah… - Journal of …, 2019 - Soc Neuroscience
It has been well documented that neurotrophins, including brain-derived neurotrophic factor
(BDNF), are severely affected in Alzheimer's disease (AD), but their administration faces a …
(BDNF), are severely affected in Alzheimer's disease (AD), but their administration faces a …
Quercetin improves cognitive disorder in aging mice by inhibiting NLRP3 inflammasome activation
H Li, FJ Chen, WL Yang, HZ Qiao, SJ Zhang - Food & Function, 2021 - pubs.rsc.org
Quercetin is one of the most abundant dietary flavonoid compounds, and its mechanism for
combating age-related neurodegenerative diseases is unclear. In this study, quercetin (35 …
combating age-related neurodegenerative diseases is unclear. In this study, quercetin (35 …
Environmental enrichment improves cognitive deficits, AD hallmarks and epigenetic alterations presented in 5xFAD mouse model
C Griñán-Ferré, V Izquierdo, E Otero… - Frontiers in Cellular …, 2018 - frontiersin.org
Cumulative evidence shows that modifications in lifestyle factors constitute an effective
strategy to modulate molecular events related to neurodegenerative diseases, confirming …
strategy to modulate molecular events related to neurodegenerative diseases, confirming …
[HTML][HTML] Fructus Ligustri Lucidi preserves bone quality through the regulation of gut microbiota diversity, oxidative stress, TMAO and Sirt6 levels in aging mice
L Li, B Chen, R Zhu, R Li, Y Tian, C Liu, Q Jia… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Gut dysbiosis and oxidative stress may trigger senile osteoporosis. Fructus Ligustri Lucidi
(FLL) has bone-preserving properties and affects the intestinal microecology. However, the …
(FLL) has bone-preserving properties and affects the intestinal microecology. However, the …
Roles of physical exercise in neurodegeneration: reversal of epigenetic clock
M Xu, JY Zhu, XD Liu, MY Luo, NJ Xu - Translational Neurodegeneration, 2021 - Springer
The epigenetic clock is defined by the DNA methylation (DNAm) level and has been
extensively applied to distinguish biological age from chronological age. Aging-related …
extensively applied to distinguish biological age from chronological age. Aging-related …
[HTML][HTML] Pharmacological inhibition of G9a/GLP restores cognition and reduces oxidative stress, neuroinflammation and β-Amyloid plaques in an early-onset …
C Griñán-Ferré, L Marsal-García… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
The implication of epigenetic mechanisms in Alzheimer's disease (AD) has been
demonstrated in several studies. UNC0642, a specific and potent inhibitor of …
demonstrated in several studies. UNC0642, a specific and potent inhibitor of …
Regulation of Alpha-Secretase ADAM10 In vitro and In vivo: Genetic, Epigenetic, and Protein-Based Mechanisms
K Endres, T Deller - Frontiers in molecular neuroscience, 2017 - frontiersin.org
ADAM10 (A Disintegrin and Metalloproteinase 10) has been identified as the major
physiological alpha-secretase in neurons, responsible for cleaving APP in a non …
physiological alpha-secretase in neurons, responsible for cleaving APP in a non …
Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice
DG Matthews, M Caruso, CF Murchison, JY Zhu… - Antioxidants, 2019 - mdpi.com
Centella asiatica (CA) herb is a traditional medicine, long reputed to provide cognitive
benefits. We have reported that CA water extract (CAW) treatment improves cognitive …
benefits. We have reported that CA water extract (CAW) treatment improves cognitive …