Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …
more than 500 million population worldwide. OA was believed to be caused by the wearing …
Obesity, inflammation, and immune system in osteoarthritis
U Nedunchezhiyan, I Varughese, ARJ Sun… - Frontiers in …, 2022 - frontiersin.org
Obesity remains the most important risk factor for the incidence and progression of
osteoarthritis (OA). The leading cause of OA was believed to be overloading the joints due to …
osteoarthritis (OA). The leading cause of OA was believed to be overloading the joints due to …
[HTML][HTML] Adipokines: new potential therapeutic target for obesity and metabolic, rheumatic, and cardiovascular diseases
L Recinella, G Orlando, C Ferrante… - Frontiers in …, 2020 - frontiersin.org
Besides its role as an energy storage organ, adipose tissue can be viewed as a dynamic
and complex endocrine organ, which produces and secretes several adipokines, including …
and complex endocrine organ, which produces and secretes several adipokines, including …
[HTML][HTML] Interleukin-6, CXCL10 and infiltrating macrophages in COVID-19-related cytokine storm: not one for all but all for one!
F Coperchini, L Chiovato, M Rotondi - Frontiers in immunology, 2021 - frontiersin.org
SARS-COV-2 virus is responsible for the ongoing devastating pandemic. Since the early
phase of the pandemic, the “cytokine-storm” appeared a peculiar aspect of SARS-COV-2 …
phase of the pandemic, the “cytokine-storm” appeared a peculiar aspect of SARS-COV-2 …
Adipose tissue is a critical regulator of osteoarthritis
KH Collins, KL Lenz, EN Pollitt… - Proceedings of the …, 2021 - National Acad Sciences
Osteoarthritis (OA), the leading cause of pain and disability worldwide, disproportionally
affects individuals with obesity. The mechanisms by which obesity leads to the onset and …
affects individuals with obesity. The mechanisms by which obesity leads to the onset and …
Recent developments in clinical applications of mesenchymal stem cells in the treatment of rheumatoid arthritis and osteoarthritis
JJ Hwang, YA Rim, Y Nam, JH Ju - Frontiers in Immunology, 2021 - frontiersin.org
Mesenchymal stem cell (MSC) therapies have been used as cell-based treatments for
decades, owing to their anti-inflammatory, immunomodulatory, and regenerative properties …
decades, owing to their anti-inflammatory, immunomodulatory, and regenerative properties …
[HTML][HTML] An up to date on clinical prospects and management of osteoarthritis
The rising prevalence of osteoarthritis (OA) in the general population has necessitated the
development of novel treatment options. It is critical to recognize the joint as a separate …
development of novel treatment options. It is critical to recognize the joint as a separate …
[HTML][HTML] Molecular classification of knee osteoarthritis
Z Lv, YX Yang, J Li, Y Fei, H Guo, Z Sun, J Lu… - Frontiers in cell and …, 2021 - frontiersin.org
Knee osteoarthritis (KOA) is the most common form of joint degeneration with increasing
prevalence and incidence in recent decades. KOA is a molecular disorder characterized by …
prevalence and incidence in recent decades. KOA is a molecular disorder characterized by …
GRB10 and E2F3 as diagnostic markers of osteoarthritis and their correlation with immune infiltration
YJ Deng, EH Ren, WH Yuan, GZ Zhang, ZL Wu, QQ Xie - Diagnostics, 2020 - mdpi.com
This study aimed to find potential diagnostic markers for osteoarthritis (OA) and analyze the
role of immune cells infiltration in this pathology. We used OA datasets from the Gene …
role of immune cells infiltration in this pathology. We used OA datasets from the Gene …
Cartilage-related collagens in osteoarthritis and rheumatoid arthritis: from pathogenesis to therapeutics
Z Ouyang, L Dong, F Yao, K Wang, Y Chen… - International Journal of …, 2023 - mdpi.com
Collagens serve essential mechanical functions throughout the body, particularly in the
connective tissues. In articular cartilage, collagens provide most of the biomechanical …
connective tissues. In articular cartilage, collagens provide most of the biomechanical …