Targeting the gut and tumor microbiota in cancer

EM Park, M Chelvanambi, N Bhutiani, G Kroemer… - Nature medicine, 2022 - nature.com
Microorganisms within the gut and other niches may contribute to carcinogenesis, as well as
shaping cancer immunosurveillance and response to immunotherapy. Our understanding of …

Clinical update on head and neck cancer: molecular biology and ongoing challenges

E Alsahafi, K Begg, I Amelio, N Raulf, P Lucarelli… - Cell death & …, 2019 - nature.com
Head and neck squamous cell carcinomas (HNSCCs) are an aggressive, genetically
complex and difficult to treat group of cancers. In lieu of truly effective targeted therapies …

Safety and tumor specificity of cetuximab-IRDye800 for surgical navigation in head and neck cancer

EL Rosenthal, JM Warram, E De Boer, TK Chung… - Clinical Cancer …, 2015 - AACR
Purpose: Positive margins dominate clinical outcomes after surgical resections in most solid
cancer types, including head and neck squamous cell carcinoma. Unfortunately, surgeons …

Update on head and neck cancer: current knowledge on epidemiology, risk factors, molecular features and novel therapies

F Pezzuto, L Buonaguro, F Caponigro, F Ionna… - Oncology, 2015 - karger.com
Tobacco use and alcohol consumption are the main risk factors associated with head and
neck squamous cell carcinoma (SCC) development due to their cytotoxic and mutagenic …

Oncologic procedures amenable to fluorescence-guided surgery

KE Tipirneni, JM Warram, LS Moore, AC Prince… - Annals of …, 2017 - journals.lww.com
Objective: Although fluorescence imaging is being applied to a wide range of cancers, it
remains unclear which disease populations will benefit greatest. Therefore, we review the …

Targeting the PI3K/AKT/mTOR pathway in squamous cell carcinoma of the head and neck

DR Simpson, LK Mell, EEW Cohen - Oral oncology, 2015 - Elsevier
Despite recent advances in novel therapies, the prognosis for patients with squamous cell
carcinoma of the head and neck (SCCHN) remains poor. Progress in understanding the …

Tissue-infiltrating immune cells as prognostic markers in oral squamous cell carcinoma: a systematic review and meta-analysis

E Hadler-Olsen, AM Wirsing - British journal of cancer, 2019 - nature.com
Background Various immune cells have been suggested as prognostic markers for cancer
patients. In this article, we present a systematic review and meta-analysis of studies …

ROS‐Mediated therapeutic strategy in Chemo‐/Radiotherapy of head and neck cancer

G Huang, ST Pan - Oxidative medicine and cellular longevity, 2020 - Wiley Online Library
Head and neck cancer is a highly genetic and metabolic heterogeneous collection of
malignancies of the lip, oral cavity, salivary glands, pharynx, esophagus, paranasal sinuses …

HPV positive head and neck cancers: molecular pathogenesis and evolving treatment strategies

R Dok, S Nuyts - Cancers, 2016 - mdpi.com
Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous disease that
is the result of tobacco and/or alcohol abuse or infection with high-risk Human …

[HTML][HTML] Tumor associated macrophages induce epithelial to mesenchymal transition via the EGFR/ERK1/2 pathway in head and neck squamous cell carcinoma

L Gao, W Zhang, WQ Zhong, ZJ Liu… - Oncology …, 2018 - spandidos-publications.com
The development of head and neck squamous cell carcinoma (HNSCC) is closely
associated with inflammation. Tumor associated macrophages (TAMs), the largest …