This review outlines the recent evidence on the role of small airway dysfunction in paediatric
asthma development and control, and addresses how the use of new diagnostic techniques …

For more than 50 years, small airways disease has been considered a key feature of chronic
obstructive pulmonary disease (COPD) and a major cause of airway obstruction. Both …

Background The involvement of small airways has recently gained greater recognition in
asthma. Impulse oscillometry (IOS) is a simple and noninvasive method based on the forced …

Involvement of small airways, those of< 2 mm in internal diameter, is present in all stages of
asthma and contributes substantially to its pathophysiologic expression. Therefore, small …

Over the past few decades, technology and improvements in artificial intelligence have
dramatically changed major sectors of our day-to-day lives, including the field of healthcare …

Airway smooth muscle (ASM) extends from the trachea throughout the bronchial tree to the
terminal bronchioles. In utero, spontaneous phasic contraction of fetal ASM is critical for …

Background The small-airway dysfunction (SAD), detected with impulse oscillometry (IOS)
methods, has been recently better characterized in patients with asthma. However, little is …

Using a therapeutic strategy that is free from traditional diagnostic labels and based on the
identification of “treatable traits”(TTs), which are influential in clinical presentations in each …

Asthma is a chronic disease, affecting approximately 350 million people worldwide.
Inflammation and remodeling in asthma involve the large airways, and it is now widely …

Background Dupilumab, a fully human monoclonal antibody, blocks the shared receptor
component for interleukin-4 and interleukin-13, key drivers of type 2 inflammation. In the …