▪ Abstract The compartmentation of eukaryotic cells requires all nuclear proteins to be
imported from the cytoplasm, whereas, for example, transfer RNAs, messenger RNAs, and …

Proteins are translated in the cytoplasm, but many need to access the nucleus to perform
their functions. Understanding how these nuclear proteins are transported through the …

Ran is a nuclear Ras-like GTPase that is required for the bidirectional transport of proteins
and ribnucleoproteins across the nuclear pore complex (NPC). A key regulator of the Ran …

NLS proteins are transported into the nucleus by the importin α/β heterodimer. Importin α
binds the NLS, while importin β mediates translocation through the nuclear pore complex …

In eukaryotic organisms, DNA replication and RNA biogenesis occur in the cell nucleus,
whereas protein synthesis occurs in the cytoplasm. Integration of these activities depends on …

The importin‐alpha/beta heterodimer and the GTPase Ran play key roles in nuclear protein
import. Importin binds the nuclear localization signal (NLS). Translocation of the resulting …

Abstract The GTPase Ran is essential for nuclear import of proteins with a classical nuclear
localization signal (NLS). Ran's nucleotide‐bound state is determined by the chromatin …

Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the importin β homologs
NMD5 and XPO1 | The EMBO Journal Skip to Article Content Skip to Article Information All …

HIV-1 Vpr promotes nuclear entry of viral nucleic acids in nondividing macrophages and
also causes a G2 cell-cycle arrest. Consistent with its role in nuclear transport, we show Vpr …

The importin-α/β complex and the GTPase Ran mediate nuclear import of proteins with a
classical nuclear localization signal. Although Ran has been implicated also in a variety of …