Importance Primary care clinicians find managing chronic pain challenging. Evidence of
long-term efficacy of opioids for chronic pain is limited. Opioid use is associated with serious …

Purpose Diabetic peripheral neuropathy (DPN) is the commonest cause of neuropathy
worldwide, and its prevalence increases with the duration of diabetes. It affects …

Background: Prescription opioid–related overdose deaths increased sharply during 1999–
2010 in the United States in parallel with increased opioid prescribing. CDC assessed …

Background: In response to adverse outcomes from prescription opioids, the Centers for
Disease Control and Prevention (CDC) released the Guideline for Prescribing Opioids for …

Opioid Abuse in Chronic Pain — Misconceptions and Mitigation Strategies | New England Journal
of Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

Background: Increases in prescriptions of opioid medications for chronic pain have been
accompanied by increases in opioid overdoses, abuse, and other harms and uncertainty …

Low back pain (LBP) is one of the major disabling health conditions among older adults
aged 60 years or older. While most causes of LBP among older adults are non-specific and …

Background Chronic pain conditions impose significant burdens worldwide.
Pharmacological treatments like opioids have limitations. Non-invasive non …

Importance Sickle cell disease (SCD) is a life-threatening genetic disorder affecting nearly
100 000 individuals in the United States and is associated with many acute and chronic …

Background: Opioid use, abuse, and adverse consequences, including death, have
escalated at an alarming rate since the 1990s. In an attempt to control opioid abuse …