Abstract Background Over 100 million Americans are living with chronic pain, and pain is the
most common reason that patients seek medical attention. Despite the prevalence of pain …

Chronic pain and prescription opioid abuse are extremely prevalent both in this country and
worldwide. Consequences of opioid misuse can be life-threatening with significant morbidity …

Background: Overdose deaths involving opioid pain relievers (OPR), also known as opioid
analgesics, have increased and now exceed deaths involving heroin and cocaine …

Opiates are among the oldest medications available to manage a number of medical
problems. Although pain is the current focus, early use initially focused upon the treatment of …

Context The rate of prescription opioid–related overdose death increased substantially in
the United States over the past decade. Patterns of opioid prescribing may be related to risk …

Objective: Increasing rates of opioid use disorders (OUDs)(abuse and dependence) among
patients prescribed opioids are a significant public health concern. We investigated the …

Importance Overprescribing of opioids is considered a major driving force behind the opioid
epidemic in the United States. Marijuana is one of the potential nonopioid alternatives that …

Executive summary We are facing a huge increase in the older population over the next 30
years. This brings an anticipated increase in the prevalence of chronic pain and with this …

Background Consensus guidelines recommend multi-modal chronic pain treatment with
increased uptake of non-pharmacological pain treatment modalities (NPMs). We aimed to …

Background Opioid analgesics play a key role in pain management but providing access
while mitigating risk of misuse and dependence remains a challenge. Tracking global …