The idea that physicians have a duty to relieve human suffering dates back to antiquity.
However, the notion that suffering can be quantified and monitored as a pain level is a much …

Clinical studies comparing the response and side effects of various opioids have not been
able to show robust differences between drugs. Hence, recommendations of the regulatory …

Background: Nonfatal opioid overdose is an opportunity to identify and treat substance use
disorders, but treatment patterns after the overdose are unknown. Objective: To determine …

Purpose The transversus abdominal plane (TAP) block has been described as an effective
pain control technique after abdominal surgery. We performed a systematic review and meta …

Purpose This review sought to (a) describe definitions of long‐term opioid therapy (LTOT)
outcome measures, and (b) identify the predictors associated with the transition from short …

Heroin is an opioid agonist commonly abused for its rewarding effects. Since its synthesis at
the end of the nineteenth century, its popularity as a recreational drug has ebbed and …

The prescribing of opioid analgesics for pain management—particularly for management of
chronic noncancer pain (CNCP)—has increased more than fourfold in the United States …

This is an article in the Core Entrustables in Clinical Pharmacology series that describes
opioid therapy in acute and chronic pain. Opioid use during surgical procedures or …

This clinical policy deals with critical issues in prescribing of opioids for adult patients treated
in the emergency department (ED). This guideline is the result of the efforts of the American …

Objective: To evaluate the efficacy and safety of tapentadol extended release (ER) for the
management of moderate to severe chronic low back pain. Research design: Patients (N …