Spermatogenesis is the process by which a single spermatogonium develops into 256
spermatozoa, one of which will fertilize the ovum. Since the 1950s when the stages of the …

Since its approval by the FDA in 1992 for the treatment of ovarian cancer, the use of Taxol
has dramatically increased. Although treatment with Taxol has led to improvement in the …

Spindle assembly required during mitosis depends on microtubule polymerization. We
demonstrate that the evolutionarily conserved low-complexity protein, BuGZ, undergoes …

The taxanes, paclitaxel and docetaxel are microtubule-stabilizing agents that function
primarily by interfering with spindle microtubule dynamics causing cell cycle arrest and …

Background MicroRNAs have been identified as crucial regulators in both animals and
plants. Here we report on a comprehensive comparative study of all known miRNA families …

Although most eukaryotic cells can express multiple isotypes of αβ-tubulin, the significance
of this diversity has not always been apparent. Recent data indicate that particular αβ-tubulin …

Starvation-induced autophagy requires activation of the ULK complex at the phagophore.
Two Golgi proteins, WAC and GM130, regulate autophagy, however their mechanism of …

We have recently reported a missense mutation in exon 4 of the tubulin alpha 1A (Tuba1a)
gene in a hyperactive N‐ethyl‐N‐nitrosourea (ENU) induced mouse mutant with abnormal …

Microtubule nucleation is the process in which several tubulin molecules interact to form a
microtubule seed. Microtubule nucleation occurs spontaneously in purified tubulin solutions …

Microtubules are fibrous elements in the cytoplasm of eukaryotic cells, where they perform a
wide variety of functions. Microtubules are major organizers of the cell interior and are vitally …