Mechanistic understanding of the toxic effects of arsenic and warfare arsenicals on human health and environment

S Muzaffar, J Khan, R Srivastava, MS Gorbatyuk… - Cell Biology and …, 2023 - Springer
Worldwide, more than 200 million people are estimated to be exposed to unsafe levels of
arsenic. Chronic exposure to unsafe levels of groundwater arsenic is responsible for …

Autophagy in extracellular matrix and wound healing modulation in the cornea

D Kempuraj, RR Mohan - Biomedicines, 2022 - mdpi.com
Autophagy is a robust cellular mechanism for disposing of harmful molecules or recycling
them to cells, which also regulates physiopathological processes in cornea. Dysregulated …

Pathophysiology and inflammatory biomarkers of sulfur mustard-induced corneal injury in rabbits

DG Goswami, N Mishra, R Kant, C Agarwal… - Plos one, 2021 - journals.plos.org
Sulfur mustard (SM) is a cytotoxic, vesicating, chemical warfare agent, first used in 1917;
corneas are particularly vulnerable to SM exposure. They may develop inflammation …

Establishing a Dexamethasone Treatment Regimen To Alleviate Sulfur Mustard–Induced Corneal Injuries in a Rabbit Model

N Mishra, R Kant, K Kandhari, N Tewari-Singh… - … of Pharmacology and …, 2024 - ASPET
Sulfur mustard (SM) is an ominous chemical warfare agent. Eyes are extremely susceptible
to SM toxicity; injuries include inflammation, fibrosis, neovascularization (NV), and vision …

Effect of dexamethasone treatment at variable therapeutic windows in reversing nitrogen mustard-induced corneal injuries in rabbit ocular in vivo model

DG Goswami, N Mishra, R Kant, C Agarwal… - Toxicology and applied …, 2022 - Elsevier
Nitrogen mustard (NM) is an analogue of the potent vesicating agent sulfur mustard, with
well-established ocular injury models in rabbit eyes to study vesicant-induced ocular toxicity …

[HTML][HTML] Oxidative stress in corneal injuries of different origin: Utilization of 3D human corneal epithelial tissue model

Y Kaluzhny, MW Kinuthia, AM Lapointe… - Experimental Eye …, 2020 - Elsevier
The purpose of the current work was to utilize a three dimensional (3D) corneal epithelial
tissue model to study dry eye disease and oxidative stress-related corneal epithelial injuries …

Dose-dependent emergence of acute and recurrent corneal lesions in sulfur mustard-exposed rabbit eyes

PM McNutt, KEM Kelly, AC Altvater, MR Nelson… - Toxicology Letters, 2021 - Elsevier
Sulfur mustard (SM) is a lipid soluble alkylating agent that causes genotoxic injury. The eye
is highly sensitive to SM toxicity and exposures exceeding 400 mg min/m 3 can elicit …

Progress towards a standardized model of ocular sulfur mustard injury for therapeutic testing

P McNutt - Experimental eye research, 2023 - Elsevier
Sulfur mustard (SM) remains a highly dangerous chemical weapon capable of producing
mass casualties through liquid or vapor exposure. The cornea is highly sensitive to SM …

Acute corneal injury in rabbits following nitrogen mustard ocular exposure

DG Goswami, R Kant, DA Ammar, D Kumar… - … and molecular pathology, 2019 - Elsevier
Sulfur mustard (SM), a potent vesicating chemical warfare agent, and its analog nitrogen
mustard (NM), are both strong bi-functional alkylating agents. Eyes, skin, and the respiratory …

Differential Efficacy of Small Molecules Dynasore and Mdivi-1 for the Treatment of Dry Eye Epitheliopathy or as a Countermeasure for Nitrogen Mustard Exposure of …

J Pan, S Pany, R Martinez-Carrasco, ME Fini - Journal of Pharmacology and …, 2024 - ASPET
The ocular surface comprises the wet mucosal epithelia of the cornea and conjunctiva, the
associated glands, and the overlying tear film. Epitheliopathy is the common pathologic …