Mechanistic understanding of the toxic effects of arsenic and warfare arsenicals on human health and environment
Worldwide, more than 200 million people are estimated to be exposed to unsafe levels of
arsenic. Chronic exposure to unsafe levels of groundwater arsenic is responsible for …
arsenic. Chronic exposure to unsafe levels of groundwater arsenic is responsible for …
Autophagy in extracellular matrix and wound healing modulation in the cornea
D Kempuraj, RR Mohan - Biomedicines, 2022 - mdpi.com
Autophagy is a robust cellular mechanism for disposing of harmful molecules or recycling
them to cells, which also regulates physiopathological processes in cornea. Dysregulated …
them to cells, which also regulates physiopathological processes in cornea. Dysregulated …
Pathophysiology and inflammatory biomarkers of sulfur mustard-induced corneal injury in rabbits
DG Goswami, N Mishra, R Kant, C Agarwal… - Plos one, 2021 - journals.plos.org
Sulfur mustard (SM) is a cytotoxic, vesicating, chemical warfare agent, first used in 1917;
corneas are particularly vulnerable to SM exposure. They may develop inflammation …
corneas are particularly vulnerable to SM exposure. They may develop inflammation …
Establishing a Dexamethasone Treatment Regimen To Alleviate Sulfur Mustard–Induced Corneal Injuries in a Rabbit Model
Sulfur mustard (SM) is an ominous chemical warfare agent. Eyes are extremely susceptible
to SM toxicity; injuries include inflammation, fibrosis, neovascularization (NV), and vision …
to SM toxicity; injuries include inflammation, fibrosis, neovascularization (NV), and vision …
Effect of dexamethasone treatment at variable therapeutic windows in reversing nitrogen mustard-induced corneal injuries in rabbit ocular in vivo model
DG Goswami, N Mishra, R Kant, C Agarwal… - Toxicology and applied …, 2022 - Elsevier
Nitrogen mustard (NM) is an analogue of the potent vesicating agent sulfur mustard, with
well-established ocular injury models in rabbit eyes to study vesicant-induced ocular toxicity …
well-established ocular injury models in rabbit eyes to study vesicant-induced ocular toxicity …
[HTML][HTML] Oxidative stress in corneal injuries of different origin: Utilization of 3D human corneal epithelial tissue model
Y Kaluzhny, MW Kinuthia, AM Lapointe… - Experimental Eye …, 2020 - Elsevier
The purpose of the current work was to utilize a three dimensional (3D) corneal epithelial
tissue model to study dry eye disease and oxidative stress-related corneal epithelial injuries …
tissue model to study dry eye disease and oxidative stress-related corneal epithelial injuries …
Dose-dependent emergence of acute and recurrent corneal lesions in sulfur mustard-exposed rabbit eyes
PM McNutt, KEM Kelly, AC Altvater, MR Nelson… - Toxicology Letters, 2021 - Elsevier
Sulfur mustard (SM) is a lipid soluble alkylating agent that causes genotoxic injury. The eye
is highly sensitive to SM toxicity and exposures exceeding 400 mg min/m 3 can elicit …
is highly sensitive to SM toxicity and exposures exceeding 400 mg min/m 3 can elicit …
Progress towards a standardized model of ocular sulfur mustard injury for therapeutic testing
P McNutt - Experimental eye research, 2023 - Elsevier
Sulfur mustard (SM) remains a highly dangerous chemical weapon capable of producing
mass casualties through liquid or vapor exposure. The cornea is highly sensitive to SM …
mass casualties through liquid or vapor exposure. The cornea is highly sensitive to SM …
Acute corneal injury in rabbits following nitrogen mustard ocular exposure
DG Goswami, R Kant, DA Ammar, D Kumar… - … and molecular pathology, 2019 - Elsevier
Sulfur mustard (SM), a potent vesicating chemical warfare agent, and its analog nitrogen
mustard (NM), are both strong bi-functional alkylating agents. Eyes, skin, and the respiratory …
mustard (NM), are both strong bi-functional alkylating agents. Eyes, skin, and the respiratory …
Differential Efficacy of Small Molecules Dynasore and Mdivi-1 for the Treatment of Dry Eye Epitheliopathy or as a Countermeasure for Nitrogen Mustard Exposure of …
J Pan, S Pany, R Martinez-Carrasco, ME Fini - Journal of Pharmacology and …, 2024 - ASPET
The ocular surface comprises the wet mucosal epithelia of the cornea and conjunctiva, the
associated glands, and the overlying tear film. Epitheliopathy is the common pathologic …
associated glands, and the overlying tear film. Epitheliopathy is the common pathologic …