Background The triple burden of COVID-19, tuberculosis and human immunodeficiency
virus is one of the major global health challenges of the twenty-first century. In high burden …

The defining pathology of tuberculosis is the granuloma, an organized structure derived from
host immune cells that surrounds infecting Mycobacterium tuberculosis. As the location of …

Abstract Development of an effective tuberculosis (TB) vaccine has suffered from an
incomplete understanding of the correlates of protection against Mycobacterium tuberculosis …

The central pathogen-immune interface in tuberculosis is the granuloma, a complex host
immune structure that dictates infection trajectory and physiology. Granuloma macrophages …

Upon infection, mycobacteria, such as Mycobacterium tuberculosis (Mtb) and
nontuberculous mycobacteria (NTM), are recognized by host innate immune cells, triggering …

Human immunodeficiency virus (HIV) and Mycobacterium tuberculosis (Mtb) are pathogens
responsible for millions of new infections each year; together, they cause high morbidity and …

The tuberculosis (TB) bacillus, Mycobacterium tuberculosis (Mtb), and HIV-1 act
synergistically; however, the mechanisms by which Mtb exacerbates HIV-1 pathogenesis …

Blood transcriptomics analysis of tuberculosis has revealed an interferon-inducible gene
signature that diminishes in expression after successful treatment; this promises improved …

Background: We aimed to visualize and classify the time series of COVID-19, tuberculosis
(TB) notification, and TB outcomes (cure, treatment abandonment, and death), verify the …

By attenuating T-cell activation, immune checkpoints (ICs) limit optimal anti-tumour
responses and IC inhibition (ICI) has emerged as a new therapy for a broad range of …