Neuroendocrine prostate cancer is a histological variant of prostate cancer that is
characterized by aggressiveness, poor clinical outcomes, and expression of neuroendocrine …

Schlafens (SLFN) are a family of genes widely expressed in mammals, including humans
and rodents. These intriguing proteins play different roles in regulating cell proliferation, cell …

Emerging evidence has suggested that patients with metastatic prostate cancer will become
resistant after receiving docetaxel (DTX) chemotherapy, but the specific regulatory …

Background Docetaxel improves overall survival (OS) in castration-resistant prostate cancer
(PCa)(CRPC) and metastatic hormone-sensitive PCa (mHSPC). However, not all patients …

Docetaxel (DTX) is a mainstay in the treatment of metastatic prostate cancer. Failure of DTX
therapy is often associated with multidrug resistance caused by overexpression of efflux …

Docetaxel (DTX) was the first chemotherapeutic agent to demonstrate significant efficacy in
the treatment of men with metastatic castration-resistant prostate cancer. However, response …

The treatment of urological cancers has been significantly improved in recent years.
However, for the advanced stages of these cancers and/or for those developing resistance …

Fungal infections pose a great threat to public health and there are only four main types of
antifungal drugs, which are often limited with toxicity, drug-drug interactions and antibiotic …

Biofluid-based biomarker tests hold great promise for precision medicine in prostate cancer
(PCa) clinical practice. Extracellular vesicles (EV) are established as intercellular …

Bioengineered 3D models that can mimic patient-specific pathologies in vitro are valuable
tools for developing and validating anticancer therapeutics. In this study, microfibrillar …