Aging is associated with chronic systemic inflammation, which contributes to the
development of many age-related diseases, including vascular disease. The world's …

The vast majority of cerebral stroke cases are caused by transient or permanent occlusion of
a cerebral blood vessel (“ischemic stroke”) eventually leading to brain infarction. The final …

Background and Purpose—Adult stem cell therapy is an experimental stroke treatment.
Here, we assessed homing and anti-inflammatory effects of bone marrow stromal cells …

The role of inflammation in neurological disorders is increasingly recognised. Inflammatory
processes are associated with the aetiology and clinical progression of migraine, psychiatric …

Inflammation is the key host-defense response to infection and injury, yet also a major
contributor to a diverse range of diseases, both peripheral and central in origin. Brain injury …

Local ischemia often causes a series of inflammatory reactions when both brain immune
cells and the peripheral immune response are activated. In the human body, the gut and …

Stroke pathology and its treatments conventionally focus on the brain. Probing inflammation,
a critical secondary cell death mechanism in stroke, has been largely relegated to the brain …

Mild traumatic brain injury (mTBI) is the most common neurological insult and leads to long-
lasting cognitive impairments. The immune system modulates brain functions and plays a …

Sex differences have been widely reported in neuroinflammatory disorders, focusing on the
contributory role of estrogen. The microvascular endothelium of the brain is a critical …

Stroke is the fourth leading cause of death in the United States and the second most
common cause of death worldwide; stroke is also the leading cause of long-term disability …