Immune targets for therapeutic development in depression: towards precision medicine
Over the past two decades, compelling evidence has emerged indicating that immune
mechanisms can contribute to the pathogenesis of major depressive disorder (MDD) and …
mechanisms can contribute to the pathogenesis of major depressive disorder (MDD) and …
Neuroinflammation and the kynurenine pathway in CNS disease: molecular mechanisms and therapeutic implications
Diseases of the central nervous system (CNS) remain a significant health, social and
economic problem around the globe. The development of therapeutic strategies for CNS …
economic problem around the globe. The development of therapeutic strategies for CNS …
Novel drug developmental strategies for treatment‐resistant depression
Major depressive disorder is a leading cause of disability worldwide. Because conventional
therapies are ineffective in many patients, novel strategies are needed to overcome …
therapies are ineffective in many patients, novel strategies are needed to overcome …
Inflammation, stress and depression: an exploration of ketamine's therapeutic profile
Highlights•Chronic stress, depression and inflammation have been consistently
linked.•Stress-induced inflammatory states can contribute to treatment resistance.•Ketamine …
linked.•Stress-induced inflammatory states can contribute to treatment resistance.•Ketamine …
[HTML][HTML] Updated review and meta-analysis of probiotics for the treatment of clinical depression: adjunctive vs. stand-alone treatment
Recent years have seen a rapid increase in the use of gut microbiota-targeting interventions,
such as probiotics, for the treatment of psychiatric disorders. The objective of this update …
such as probiotics, for the treatment of psychiatric disorders. The objective of this update …
Targeting inflammation: a potential approach for the treatment of depression
Major depressive disorder (MDD) or Depression is one of the serious neuropsychiatric
disorders affecting over 280 million people worldwide. It is 4th important cause of disability …
disorders affecting over 280 million people worldwide. It is 4th important cause of disability …
Neuroinflammatory alterations in trait anxiety: modulatory effects of minocycline
S Rooney, A Sah, MS Unger, M Kharitonova… - Translational …, 2020 - nature.com
High trait anxiety is a substantial risk factor for developing anxiety disorders and depression.
While neuroinflammation has been identified to contribute to stress-induced anxiety, little is …
While neuroinflammation has been identified to contribute to stress-induced anxiety, little is …
Brain-immune crosstalk in the treatment of major depressive disorder
I Branchi, S Poggini, L Capuron, F Benedetti… - European …, 2021 - Elsevier
A growing number of studies are pointing out the need for a conceptual shift from a brain-
centered to a body-inclusive approach in mental health research. In this perspective, the link …
centered to a body-inclusive approach in mental health research. In this perspective, the link …
Tolerance-inducing effect and properties of innate immune stimulation on chronic stress-induced behavioral abnormalities in mice
Y Gu, T Ye, P Tan, L Tong, J Ji, Y Gu, Z Shen… - Brain, Behavior, and …, 2021 - Elsevier
Over-activation of the innate immune system constitutes a risk factor for the development of
nervous system disorders but may reduce the severity of these disorders by inducing …
nervous system disorders but may reduce the severity of these disorders by inducing …
Depression interacts with allostatic load to predict cognitive decline in middle age
Background Allostatic load (AL) indicates the cumulative impact of stress on homeostatic
mechanisms. Depression and AL have been associated with cognitive deficits, but it is …
mechanisms. Depression and AL have been associated with cognitive deficits, but it is …