PI3K/Akt/mTOR signaling regulates diverse cellular processes. Abnormal PI3K/Akt/mTOR
signaling is a characteristic feature of cancer. As such inhibition of PI3K/Akt/mTOR signaling …

Rheumatoid arthritis (RA) is a systemic-autoimmune-mediated disease characterized by
synovial hyperplasia and progressive destruction of joint. Currently available biological …

Gallbladder cancer (GBC) is the most common malignant tumour of the biliary track system.
Angiogenesis plays a pivotal role in the development and progression of malignant tumours …

Angiogenesis is an important phenomenon in the pathogenesis of some diseases, such as
numerous types of tumors and autoimmunity, and also a number of soluble and cell‐bound …

The interest on the endocannabinoid system (ECS) in human reproduction has grown due to
its involvement in placenta development, which led to growing concerns over pregnant …

Materials and methods Literature search was carried out using 'oncostatin'as a keyword. The
interpreted information regarding OSM signaling cascade was recorded in 'PathBuilder,'a …

Inflammatory response and articular destruction are common symptoms of osteoarthritis
(OA) and rheumatoid arthritis (RA). Leptin, an adipocyte-secreted hormone that centrally …

We previously demonstrated that propofol, an intravenous anesthetic with anti-oxidative
properties, activated the phosphoinositide 3-kinase (PI3K)/AKT pathway to increase the …

Excessive post‐operative wound healing with subsequent scarring frequently leads to
surgical failure of glaucoma filtration surgery (trabeculectomy). We investigated the …

Immunomodulation contributes to the antitumor efficacy of the fractionated radiation therapy
(RT). Here, we describe immune effects of RT with concurrent systemic cisplatin or …