BACKGROUND Each organ in the human body has its own capillary bed to carry out its
distinctive and versatile functions in response to dynamically changing systemic and local …

Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …

Heterogeneity of lung tumor endothelial cell (TEC) phenotypes across patients, species
(human/mouse), and models (in vivo/in vitro) remains poorly inventoried at the single-cell …

To maintain physiological homeostasis, cell turnover occurs every day in the body via a form
of programmed cell death called apoptosis. During apoptosis, cells undergo distinct …

Complex multicellular life in mammals relies on functional cooperation of different organs for
the survival of the whole organism. The kidneys play a critical part in this process through …

Atherosclerosis remains a major cause of morbidity and mortality worldwide, and a thorough
understanding of the underlying pathophysiological mechanisms is crucial for the …

Objective—Cellular metabolism was recently shown to regulate endothelial cell phenotype
profoundly. Whether the atheroprotective biomechanical stimulus elicited by laminar shear …

The hierarchical organization of properly sized blood vessels ensures the correct distribution
of blood to all organs of the body, and is controlled via haemodynamic cues. In current …

It is well accepted that atherosclerosis occurs in a site-specific manner especially at branch
points where disturbed blood flow (d-flow) predisposes to the development of plaques …

Neurological diseases, including acute attacks (eg, ischemic stroke) and chronic
neurodegenerative diseases (eg, Alzheimer's disease), have always been one of the …