[HTML][HTML] Targeted therapies for pediatric AML: gaps and perspective

A Lonetti, A Pession, R Masetti - Frontiers in pediatrics, 2019 - frontiersin.org
Acute myeloid leukemia (AML) is a hematopoietic disorder characterized by numerous
cytogenetic and molecular aberrations that accounts for~ 25% of childhood leukemia …

Pediatric acute myeloid leukemia: Insight into genetic landscape and novel targeted approaches

N Tosic, I Marjanovic, J Lazic - Biochemical Pharmacology, 2023 - Elsevier
Acute myeloid leukemia (AML) is a very heterogeneous hematological malignancy that
accounts for approximately 20% of all pediatric leukemia cases. The outcome of pediatric …

[HTML][HTML] Occurrence of treatment-related cardiotoxicity and its impact on outcomes among children treated in the AAML0531 clinical trial: a report from the Children's …

KD Getz, L Sung, B Ky, RB Gerbing… - Journal of Clinical …, 2019 - ncbi.nlm.nih.gov
Purpose Late cardiotoxicity after pediatric acute myeloid leukemia therapy causes
substantial morbidity and mortality. The impact of early-onset cardiotoxicity on treatment …

[HTML][HTML] Effect of dexrazoxane on left ventricular systolic function and treatment outcomes in patients with acute myeloid leukemia: a report from the Children's …

KD Getz, L Sung, TA Alonzo, KJ Leger… - Journal of Clinical …, 2020 - ncbi.nlm.nih.gov
Effect of Dexrazoxane on Left Ventricular Systolic Function and Treatment Outcomes in Patients
With Acute Myeloid Leukemia: A Report From the Children’s Oncology Group - PMC Back to …

Prognostic impact of t (16; 21)(p11; q22) and t (16; 21)(q24; q22) in pediatric AML: a retrospective study by the I-BFM Study Group

S Noort, M Zimmermann, D Reinhardt… - Blood, The Journal …, 2018 - ashpublications.org
To study the prognostic relevance of rare genetic aberrations in acute myeloid leukemia
(AML), such as t (16; 21), international collaboration is required. Two different types of t (16; …

[HTML][HTML] Analysis of rare driving events in pediatric acute myeloid leukemia

S Noort, J van Oosterwijk, J Ma, EAR Garfinkle… - …, 2023 - ncbi.nlm.nih.gov
Elucidating genetic aberrations in pediatric acute myeloid leukemia (AML) provides insight
in biology and may impact on risk-group stratification and clinical outcome. This study aimed …

Genome-wide CRISPR/Cas9 screen identifies etoposide response modulators associated with clinical outcomes in pediatric AML

NHK Nguyen, R Rafiee, A Tagmount, A Sobh… - Blood …, 2023 - ashpublications.org
Etoposide is used to treat a wide range of malignant cancers, including acute myeloid
leukemia (AML) in children. Despite the use of intensive chemotherapeutic regimens …

Long non-coding RNA UCA1 modulates cell proliferation and apoptosis by regulating miR-296-3p/Myc axis in acute myeloid leukemia

J Li, M Wang, X Chen - Cell cycle, 2020 - Taylor & Francis
Acute myeloid leukemia (AML) is a common hematopoietic malignancy with a generally
poor prognosis. Long non-coding RNA (lncRNA) urothelial carcinoma-associated 1 (UCA1) …

Outcome of pediatric acute myeloid leukemia (AML) in low-and middle-income countries: a systematic review of the literature

RE Van Weelderen, K Klein… - Expert Review of …, 2021 - Taylor & Francis
Introduction: Survival rates of pediatric acute myeloid leukemia (AML) in low-and middle-
income countries (LMICs) seem extremely poor, and the available literature on the matter is …

[HTML][HTML] The role of forkhead box proteins in acute myeloid leukemia

C Gurnari, G Falconi, E De Bellis, MT Voso, E Fabiani - Cancers, 2019 - mdpi.com
Forkhead box (FOX) proteins are a group of transcriptional factors implicated in different
cellular functions such as differentiation, proliferation and senescence. A growing number of …