PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer
A Glaviano, ASC Foo, HY Lam, KCH Yap, W Jacot… - Molecular cancer, 2023 - Springer
Abstract The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal
transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell …
transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell …
The role of PI3K/AKT/mTOR signaling in hepatocellular carcinoma metabolism
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths in
the world. Metabolic reprogramming is considered a new hallmark of cancer, but it remains …
the world. Metabolic reprogramming is considered a new hallmark of cancer, but it remains …
Targeting the PI3K/AKT/mTOR and RAF/MEK/ERK pathways for cancer therapy
Q Li, Z Li, T Luo, H Shi - Molecular biomedicine, 2022 - Springer
Abstract The PI3K/AKT/mTOR and RAF/MEK/ERK pathways are commonly activated by
mutations and chromosomal translocation in vital targets. The PI3K/AKT/mTOR signaling …
mutations and chromosomal translocation in vital targets. The PI3K/AKT/mTOR signaling …
Anticancer potential of the plant‐derived Saponin Gracillin: a comprehensive review of mechanistic approaches
MS Bhuia, R Chowdhury, FA Sonia… - Chemistry & …, 2023 - Wiley Online Library
With the increasing prevalence of cancer and the toxic side effects of synthetic drugs, natural
products are being developed as promising therapeutic approaches. Gracillin is a naturally …
products are being developed as promising therapeutic approaches. Gracillin is a naturally …
Recent advances in PI3K/PKB/mTOR inhibitors as new anticancer agents
MA Occhiuzzi, G Lico, G Ioele, M De Luca… - European Journal of …, 2023 - Elsevier
The biochemical role of the PI3K/PKB/mTOR signalling pathway in cell-cycle regulation is
now well known. During the onset and development of different forms of cancer it becomes …
now well known. During the onset and development of different forms of cancer it becomes …
Targeting breast cancer: An overlook on current strategies
D Iacopetta, J Ceramella, N Baldino… - International Journal of …, 2023 - mdpi.com
Breast cancer (BC) is one of the most widely diagnosed cancers and a leading cause of
cancer death among women worldwide. Globally, BC is the second most frequent cancer …
cancer death among women worldwide. Globally, BC is the second most frequent cancer …
Screening the possible anti-cancer constituents of Hibiscus rosa-sinensis flower to address mammalian target of rapamycin: an in silico molecular docking, HYDE …
One of the most common malignancies diagnosed and the leading cause of death for cancer-
stricken women globally is breast cancer. The molecular subtype affects therapy options …
stricken women globally is breast cancer. The molecular subtype affects therapy options …
Targeting transcription factor YY1 for cancer treatment: current strategies and future directions
Simple Summary Cancer is a global health problem with severe consequences. Certain
genes, known as transcription factors (TFs), are overactive in many tumors. Targeting these …
genes, known as transcription factors (TFs), are overactive in many tumors. Targeting these …
Role of mammalian target of rapamycin (mTOR) signalling in oncogenesis
The signalling system known as mammalian target of rapamycin (mTOR) is believed to be
required for several biological activities involving cell proliferation. The serine-threonine …
required for several biological activities involving cell proliferation. The serine-threonine …
[HTML][HTML] FOXO1, a tiny protein with intricate interactions: Promising therapeutic candidate in lung cancer
M Ebrahimnezhad, M Natami, GH Bakhtiari… - Biomedicine & …, 2023 - Elsevier
Nowadays, lung cancer is the most common cause of cancer-related deaths in both men
and women globally. Despite the development of extremely efficient targeted agents, lung …
and women globally. Despite the development of extremely efficient targeted agents, lung …