To date, no vaccines or effective drugs have been approved to prevent or treat COVID-19
and the current standard care relies on supportive treatments. Therefore, based on the fast …

Monoclonal antibodies (mAbs) have become one of the most important classes of
biopharmaceutical products, and they continue to dominate the universe of …

Ferroptosis is a nonapoptotic cell death process that requires cellular iron and the
accumulation of lipid peroxides. In progressive rheumatoid arthritis (RA), synovial fibroblasts …

Alzheimer's disease (AD) is a neurodegenerative disease associated with human aging.
Ten percent of individuals over 65 years have AD and its prevalence continues to rise with …

Although initially described as an anti-tumor mediator, tumor necrosis factor-alpha (TNF) is
generally considered as the master pro-inflammatory cytokine. It plays a crucial role in the …

Tumor necrosis factor (TNF)-α, a key mediator of intestinal inflammation, causes an increase
in intestinal epithelial tight junction (TJ) permeability by activating myosin light chain kinase …

Inflammatory bowel disease (IBD) is an idiopathic chronic inflammatory disease of the
gastrointestinal system. The spectrum is of predominantly two types, namely, ulcerative …

Abstract COVID-19, coronavirus disease 2019, caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has become a pandemic. At the time of writing this …

The development of anti-drug antibodies (ADAs) is a common cause for treatment failure
and hypersensitivity reactions for many biologics. The focus of this review is the …

The prevalence of immune-mediated disorders, including autoimmune conditions and
allergies, is steadily increasing. However, current therapeutic approaches are often non …