Similar morphological, physiological, and behavioral features have evolved independently
in different species, a pattern known as convergence. It is known that morphological …

Ovol2 belongs to the Ovo family of evolutionarily conserved zinc finger transcription factors
that act downstream of key developmental signaling pathways including Wg/Wnt and …

To achieve a highly differentiated state, cells undergo multiple transcriptional processes
whose coordination and timing are not well understood. In Drosophila embryonic epidermal …

Molecular genetic analysis of phenotypic variation has revealed many examples of
evolutionary change in the developmental pathways that control plant and animal …

In Drosophila, differentiation of the epidermis results in a stereotyped array of cells with F-
actin-based extensions at their apical face. We identified Ovo/Shavenbaby (Svb) as a …

Abstract Background Anaplastic Thyroid Cancer (ATC) is an undifferentiated and aggressive
tumor that often originates from well-Differentiated Thyroid Carcinoma (DTC) through a trans …

Mesenchymal-to-epithelial transition (MET) is an important step in cell reprogramming from
fibroblasts (a cell type frequently used for this purpose) to various epithelial cell types …

Body structures of Drosophila develop through transient developmental units, termed
parasegments, with boundaries lying between the adjacent expression domains of wingless …

Wnt signaling generates pattern in all animal embryos, from flies and worms to humans, and
promotes the undifferentiated, proliferative state critical for stem cells in adult tissues …

The terminal differentiation of epithelial cells involves changes in the apical compartment,
including remodeling of the cytoskeleton and junctions to modify its three-dimensional …