The RAF/MEK/ERK signaling pathway regulates diverse cellular processes as exemplified
by cell proliferation, differentiation, motility, and survival. Activation of ERK1/2 generally …

Despite significant technological advancements in conventional therapies, cancer remains
one of the main causes of death worldwide. Although substantial progress has been made …

Shikonin and its enantiomeric analogue, alkaninn, are prevailing natural lead compounds in
the drug discovery and development of anticancer agents. Despite having numerous …

Melanoma is recognized as the most dangerous type of skin cancer, with high mortality and
resistance to currently used treatments. To overcome the limitations of the available …

Background: Shikonin, a small molecule inhibitor of pyruvate kinase 2 (PKM2), has been
demonstrated to play the antitumor effect in various cancers. However, the specific effects …

Currently, skin injuries have a serious impact on people's lives and socio-economic stress.
Shikonin, a naphthoquinone compound derived from the root of the traditional Chinese …

Melanoma, the deadliest type of skin cancer, is on the rise globally. The generally poor
prognosis makes melanoma still an enormous public health problem. Ferroptosis is a newly …

Skin cutaneous melanoma (SKCM) is a skin cancer type characterized by a high degree of
immune cell infiltration. The potential function of lactate, a main metabolic product in the …

Cancer encompasses a group of pathologies with common characteristics, high incidence,
and prevalence in all countries. Although there are treatments available for this disease …

This study evaluates protosappanin B's (PSB) role in inflammation, proliferation, and
subsequent apoptosis of human melanoma A875 cells. The cell lines were treated with PSB …