Lipotoxicity is characterized by the ectopic accumulation of lipids in organs different from
adipose tissue. Lipotoxicity is mainly associated with dysfunctional signaling and insulin …

The role of the macrophage is an area of emerging interest in tendinopathy and tendon
healing. The macrophage has been found to play a key role in regulating the healing …

All mammalian cell membranes contain cholesterol to maintain membrane integrity. The
transport of this hydrophobic lipid is mediated by lipoproteins. Cholesterol is especially …

Sterol regulatory element binding protein (SREBP) cleavage activating protein (SCAP) is a
key regulator of SREBP maturation. SCAP induces translocation of SREBP from the …

Acute ischemic stroke (AIS) is a serious and life-threatening disease worldwide. Despite
thrombolysis or endovascular thrombectomy, a sizeable fraction of patients with AIS have …

Abstract Advanced Glycation End-Products (AGEs) have been recently related to the onset
of metabolic diseases and related complications. Moreover, recent findings indicate that …

Nephropathy has become the most common reason for end-stage renal disease worldwide.
The progression of end-stage renal disease occurs caused by decreased glomerular …

The present study is to investigate whether inflammatory cytokines inhibit ABCA1/ABCG1-
mediated cholesterol efflux by regulating miR-33a-5P in THP-1 macrophages. We used …

Simple Summary Dairy cows fed high levels of protein to increase milk yield tend to have
reduced fertility but the reasons behind this are unclear. Differing dietary protein levels are …

Sterol regulatory element-binding protein 2 (SREBP-2), is a well-known transcriptional
regulator of cholesterol metabolism. SREBP-2 is activated unconventionally to promote …