The aim of the investigation was to prepare and characterize microemulsion/mucoadhesive
microemulsion of tacrine (TME/TMME), assess its pharmacokinetic and pharmacodynamic …

Background Donepezil hydrochloride (Aricept) is a selective acetylcholinesterase inhibitor
developed for the treatment of Alzheimer disease. This phase 3 study was 1 of 2 pivotal trials …

Abstract Acetylcholinesterase (AChE, EC 3.1. 1.7) inhibitors are the only registered drugs
used to treat Alzheimer's disease (AD). New AChE inhibitors may contribute to the design of …

Aim The aim of this study was to characterize the pharmacokinetic and pharmacodynamic
profile of donepezil HCl, a chemically distinct and specific acetylcholinesterase (AChE) …

This review discusses the laboratory and clinical research supporting the rationale for the
efficacy of donepezil (Aricept® USA) in enhancing cognition in autism, Alzheimer disease …

We examined the effects of thioperamide and (R)-α-methylhistamine, a histamine H3-
receptor antagonist and an agonist, respectively, on a scopolamine-induced learning deficit …

The purpose of this study was the development of multifunctional liposomes for nasal
administration of tacrine hydrochloride. Liposomes were prepared using traditional …

It has been proposed that excitotoxic damage by glutamatergic hyperactivity is responsible
for neurodegeneration in Alzheimer's disease. Lamotrigine (LTG) inhibits presynaptic …

Patients susceptible to or suffering from central nervous system disorders (eg,
neurodegenerative diseases including presenile dementia, senile dementia of the …

The cholinergic anti-inflammatory pathway controls the inflammatory response and
nonreflexive consciousness through bidirectional communication between the brain and …