The cell nucleus is an interesting target in many diseases with particular interest in cancer.
Previously, nuclear targeted small and large chitosan nanoparticles (S-NPs≈ 25 nm, and L …

In this study, doxorubicin (DOX) was physically incorporated into pH-sensitive micelles
made from a mixture of poly (l-histidine)-b-poly (ethylene glycol)/poly (l-lactide)-b-poly …

A panel of phosphorescent oligoarginine conjugates of tetracarboxylic Pt (II)-coproporphyrin
I dye (PtCP), monosubstituted with long peptides or tetra-substituted with short peptides and …

Exploiting new non-metal-based peroxidase-mimic nanoenzymes for chemodynamic
therapy (CDT) in cancer treatment is an active and challenging field. Here, we found that …

Targeting of drug delivery systems (DDSs) to specific intracellular organelles (ie, subcellular
targeting) has been investigated in numerous publications, but targeting efficiency of these …

While efficient methods for cell line transfection are well described, for primary neurons a
high-yield method different from those relying on viral vectors is lacking. Viral vector-based …

Periodontitis is a persistent inflammation of the soft tissue around the teeth that affects 60%
of the population in the globe. The self-maintenance of the inflammatory process can cause …

Many drugs have been designed to act on intracellular targets and to affect intracellular
processes inside target cells. For the desired effects to be exerted, these drugs should …

The purpose of the present study was to develop a new nanoparticulate formulation for
delivery of tacrolimus to reduce its kidney distribution and functional nephrotoxicity …

Intracellular drug delivery using colloidal biomimetic calcium phosphate apatites as
nanocarriers is a seducing concept. However, the colloid preparation to an industrial scale …